Abstract
BK virus (BKV) is the cause of nephropathy. Because BKV nephropathy can progress to graft loss, early diagnosis of BKV infection is very important. In this study, we aimed to investigate the utility of quantifying cells with intranuclear inclusion bodies (decoy cells) in urinary sediment for the screening and monitoring of BKV infection in renal transplant recipients at our hospital. This was a retrospective single-center study. Urine sediment examination was performed at each outpatient visit, and the number of decoy cells was measured in the whole microscopic field. Patients (n = 41) were divided into the BK viremia group (blood positive for BKV DNA by polymerase chain reaction [PCR]) and non-BK viremia group (blood negative for BKV DNA by PCR), and the decoy cell count in urinary sediments was examined. The maximum decoy cell count was significantly higher (P= 0.04) in the BK viremia group than in the non-BK viremia group. In the receiver operating characteristic curve for the maximum decoy cells, the cutoff value was 507 cells. The area under the receiver operating characteristic curve was 0.8774 (95% confidence interval, 0.7739-0.9810). The number of decoy cells at the time of appearance in the BK viremia group was not sig...Continue Reading
References
Jun 19, 1971·Lancet·S D GardnerB Hulme
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R PurighallaP Randhawa
Dec 2, 1999·Immunologic Research·L GinaldiD Quaglino
Oct 31, 2001·Clinical Transplantation·Y M BarriS R Abul-Ezz
Aug 16, 2002·The New England Journal of Medicine·Hans H HirschJürg Steiger
Jul 15, 2003·Journal of Medical Virology·Wendy A KnowlesElizabeth Miller
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel L BohlDaniel C Brennan
May 13, 2009·The Journal of Infectious Diseases·Adrian EgliHans H Hirsch
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K MasutaniP Randhawa
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H H HirschUNKNOWN AST Infectious Diseases Community of Practice
Feb 28, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Deirdre Sawinski, Simin Goral
Jan 19, 2016·Nephrology·Jagadish S Jamboti
Mar 24, 2016·Transplantation·Sobhana ThangarajuJohn Gill
Citations
Dec 17, 2019·Diagnostic Cytopathology·Santosh TummidiAmey Rojekar
Dec 16, 2020·Viruses·Marija Burek KamenaricRenata Zunec
Dec 12, 2020·Viruses·Faisal KlufahIryna V Samarska
Mar 1, 2020·Transplantation Proceedings·Lizhi YanJinlin Liu
Apr 4, 2021·Viruses·Chia-Lin ShenChih-Yu Yang