PMID: 8582515Oct 1, 1995Paper

Prediction of early pregnancy outcomes

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Y S Lin, C H Liu

Abstract

A prospective study was performed on the conception hormones of early pregnancy in order to examine their sensitivity and predictability for early pregnancy loss. The serum levels of progesterone, estradiol and human chorionic gonadotropin (hCG) were measured and analyzed at 5-8 weeks of gestation in pregnancies occurring both with and without ovarian stimulation. If a level of < 10 ng/ml of progesterone was chosen as the cut-off value for the prediction of early pregnancy loss, the sensitivity and specificity were 56% and 98%, respectively. The optimal cut-off value was chosen at < 0.5 multiples of the median (MoM) and < 0.4 MoM for estradiol and hCG, respectively. This gave a sensitivity of 80% for estradiol and 85% for hCG, and a specificity of 93% for estradiol and 81% for hCG at week 8 of gestation. The combined determination of conception hormones is an efficacious method of monitoring early pregnancy and may be used for predicting outcome.

References

May 1, 1978·American Journal of Obstetrics and Gynecology·G D BraunsteinM E Wade
Jul 1, 1990·Human Reproduction·M HahlinB Lindblom
Oct 1, 1989·British Journal of Obstetrics and Gynaecology·P G WhittakerT Lind
Aug 1, 1986·American Journal of Obstetrics and Gynecology·R RomeroJ C Hobbins
Jul 15, 1985·American Journal of Obstetrics and Gynecology·D K RichardsonS G Gabbe
Dec 15, 1983·American Journal of Obstetrics and Gynecology·M O AspillagaT Lind

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Citations

Nov 1, 1997·Trends in Ecology & Evolution·L S Forbes
Jul 1, 2015·Current Opinion in Obstetrics & Gynecology·Israel Ortega, Juan Antonio García Velasco

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