Prediction of extraprostatic extension by prostate specific antigen velocity, endorectal MRI, and biopsy Gleason score in clinically localized prostate cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
Koshiro NishimotoMasaru Murai

Abstract

To investigate the clinical value of prostate specific antigen velocity (PSAV) in predicting the extraprostatic extension of clinically localized prostate cancer. One hundred and three patients who underwent radical prostatectomy for clinically localized prostate cancer were included in the analysis. The correlation between preoperative parameters, including PSA-based parameters, clinical stage, and histological biopsy findings, and the pathological findings were analyzed. Logistic regression analysis was performed to identify a significant set of independent predictors for the local extent of the disease. Sixty-four (60.2%) patients had organ confined prostate cancer and 39 (39.8%) patients had extraprostatic cancer. The biopsy Gleason score, PSA, PSA density, PSA density of the transition zone, and PSAV were significantly higher in the patients with extraprostatic cancer than in those with organ confined cancer. Multivariate logistic regression analysis indicated that the biopsy Gleason score, endorectal magnetic resonance imaging findings, and PSAV were significant predictors of extraprostatic cancer (P < 0.01). Probability curves for extraprostatic cancer were generated using these three preoperative parameters. The combina...Continue Reading

References

May 9, 2001·The Journal of Urology·P L RossM W Kattan
Jan 17, 2002·The Journal of Urology·Gerald W HullPeter T Scardino
Jul 13, 2004·The New England Journal of Medicine·Anthony V D'AmicoWilliam J Catalona

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Citations

Oct 30, 2020·The International Journal of Biostatistics·Katharina SeligDonna Ankerst

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