PMID: 9184953May 1, 1997Paper

Prediction of fetal lung maturity from near-infrared spectra of amniotic fluid

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
K Z LiuH H Mantsch

Abstract

The aim of this study was to attempt to correlate the quantitative data obtained from the near-infrared (near-IR) spectra of amniotic fluid with the lecithin/sphingomyelin (L/S) ratio determined from thin layer chromatographic analysis on the same samples, in order to establish the feasibility of near-IR spectroscopy as an alternate method for the prediction of fetal lung development. Samples of amniotic fluid were obtained by amniocentesis from 52 patients between the 26th and 41st week of pregnancy. About 350 microliters of amniotic fluid was required to record the near-IR spectrum over the entire spectral range between 400 and 2500 nm using a commercial spectrometer. The L/S ratio was determined independently by thin layer chromatography (TLC) for each sample. For correlating the infrared spectra with the TLC-based L/S ratios, a partial least squares analysis was used. The L/S ratios predicted from the near-IR spectra of amniotic fluid were highly correlated and in excellent agreement with those determined by TLC (r = 0.91). Near-IR spectroscopy has the potential to become an alternate method to TLC for prediction of fetal pulmonary maturity.

References

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Citations

Feb 16, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu Sakudo
Aug 2, 2000·American Journal of Obstetrics and Gynecology·K Z LiuH H Mantsch
Oct 13, 1998·Annals of Clinical Biochemistry·R A ShawH H Mantsch
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Henry Horst Mantsch
Jun 10, 1998·Analytical Biochemistry·R A ShawH H Mantsch
Feb 20, 1998·Biophysical Chemistry·M JacksonH H Mantsch

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