PMID: 46714Jan 15, 1975

Prediction of fetal outcome in threatened abortion by maternal serum placental lactogen and alpha fetoprotein

American Journal of Obstetrics and Gynecology
L Garoff, M Seppälä


Abnormally low human placental lactogen (HPL) or high alpha fetoprotein (AFP) levels in maternal serum are unfavorable prognostic signs in women with threatened abortion but normal levels cannot be used to discriminate between viable and nonviable pregnancies. Out of 112 women with threatened abortion, 69 aborted; of these, 36 had a low HPL level and they all aborted. Five women had an increased AFP concentration. Four of these aborted and the remaining case was a twin pregnancy in which one fetus died and the other survived. HPL and AFP levels provide complementary information as to the fetal outcome in threatened abortion. This was indicated by a normal HPL level in all of the five cases with raised maternal AFP, and by a normal AFP level in 35 of the 36 women with low maternal HPL.


Dec 1, 1976·Environmental Health Perspectives·S Fabro
May 1, 1977·British Journal of Obstetrics and Gynaecology·N WaldG M Stirrat
Aug 16, 1980·British Medical Journal
Apr 1, 1984·British Journal of Obstetrics and Gynaecology·H T SalemT Chard
May 1, 1978·British Journal of Obstetrics and Gynaecology·M J BennettA C Turnbull
Jan 1, 1985·British Journal of Obstetrics and Gynaecology·J G WestergaardJ G Grudzinskas
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·B F Crandall
Sep 5, 1987·British Medical Journal·C EverettI Chalmers
May 17, 1980·British Medical Journal·D H SmithJ G Grudzinskas
Aug 1, 1977·British Journal of Obstetrics and Gynaecology·P C ClarkeA T Letchworth
Aug 22, 1975·Annals of the New York Academy of Sciences·M Seppälä
Jul 29, 1977·Archiv für Gynäkologie·J Zander, B Nitsch
May 17, 1980·British Medical Journal·I N ScobieA C MacCuish
Apr 1, 1983·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J B Hertz, P Schultz-Larsen

Related Concepts

Human Placental Lactogen
Entire Fetus
Antenatal Screening Procedures
Fetal Proteins
Lactogen, Human Placental (HPL) Human Chorionic Somatomammotropin
Abortion, Tubal
Gestational Age
CSH1 gene
Multiple Pregnancy
CSH2 gene

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