Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Masanori HirotaShunji Sano

Abstract

Cardiac function of non-heart-beating donors (NHBDs) is uncertain due to severe myocardial damage. We developed an isolated myocardial perfusion system to resuscitate NHBD hearts and attempted to predict functional recovery of 60-minute warm ischemic hearts by analyzing systolic and diastolic functions. Hypoxic cardiac arrest was induced in 8 mongrel dogs without any pre-treatments. After 60-minute ischemia, intracoronary microthrombi were flushed out by retrograde blood cardiopledia with tissue-type plasminogen activator. Coronary arteries were initially perfused from the aortic root with tepid hyperkalemic blood (20 mmol/liter) at low pressure (20 mm Hg) for the first 60 minutes and then with normothermic blood for the next 60 minutes. After 120 minutes of reperfusion, pre-load was increased for ejection against an after-load of 80 mm Hg. Pressure-volume loops were recorded to obtain the end-systolic pressure-volume relationship (ESPVR) and end-diastolic pressure-volume relationship (EDPVR). Stroke volume at a given pre-load was calculated from averaged ESPVR, EDPVR and after-load identical to an averaged baseline value. The Frank-Starling relationship was obtained and cardiac status was classified according to Forrester's he...Continue Reading

References

Apr 1, 1967·Circulation·R D Wuerflein, N E Shumway
Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J MartinF Beyersdorf
Jun 19, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D K Cooper

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Citations

Mar 19, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joevin SourdonSarah L Longnus
Jan 19, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C W WhiteD H Freed
May 25, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masanori HirotaShunji Sano
Mar 17, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Satoru OsakiShunji Sano
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ilhan InciWalter Weder
Jul 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A A AliD H Freed
Sep 1, 2015·Canadian Journal of Physiology and Pharmacology·Christopher W WhiteDarren Freed
Jan 17, 2015·The Journal of Surgical Research·Shiliang LiGábor Szabó
Jul 23, 2009·Current Opinion in Organ Transplantation·Jean de Ville de Goyet
Mar 1, 2018·Frontiers in Cardiovascular Medicine·Christopher W WhiteDarren H Freed
Apr 17, 2014·Nature Reviews. Cardiology·Sarah L LongnusHendrik T Tevaearai
Apr 19, 2019·Circulation. Heart Failure·Petra NiederbergerSarah L Longnus

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