Prediction of glomerular filtration rate in renal transplant recipients: cystatin C or modification of diet in renal disease equation?

Clinical Transplantation
U PögeR P Woitas

Abstract

To overcome disadvantages of serum creatinine two strategies have been suggested to identify patients with reduced glomerular filtration rate (GFR). On the one hand, the Modification of Diet in Renal Disease (MDRD) equation is now recommended to classify the stage of chronic kidney disease. On the other hand, cystatin C (Cys C) has been investigated in numerous studies, finding a higher sensitivity than creatinine in detecting diminished GFR. To date, no comparison of both strategies in patients after renal transplantation has been performed. One hundred and five consecutive renal transplant recipients underwent (99m)Tc-DTPA-- clearance measurement. Simultaneously, MDRD estimates were calculated and Cys C serum levels were determined. ROC analyses were performed at different decision points from 20 to 70 mL/min/1.73 m(2). Although the area under the curve did not differ significantly between MDRD and Cys C within the tested GFR range, the AUC for Cys C tended to be higher when GFR exceeded 55 mL/min/1.73 m(2). A significantly higher diagnostic accuracy for Cys C compared with MDRD (p = 0.045 at 65 mL/min/1.73 m(2)) was found when investigating the subgroup of patients with well-functioning grafts (GFR>40 mL/min/1.73 m(2)). MDRD...Continue Reading

References

Nov 1, 1985·Kidney International·O ShemeshB D Myers
Aug 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E A RossG M Danovitch
Oct 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Larsen
Nov 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·M BjarnadóttirI Olafsson
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L RischA Huber
Aug 26, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·N CimermanJ Kos
Aug 26, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·S Herget-RosenthalA Kribben
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luis CarrerasMarta Carrera
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Andrew G BostomEberhard Ritz
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vikas R DharnidharkaGary Stevens
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Julie LinAjay K Singh
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul A SkluzacekPablo E Pergola
Jan 20, 2004·Journal of Clinical Laboratory Analysis·Davis Massey
Oct 13, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Flavio GaspariUNKNOWN MY.S.S. Study Investigators
Oct 22, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Uwe PögeRainer P Woitas

❮ Previous
Next ❯

Citations

Feb 8, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Qi LingShusen Zheng
Nov 1, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Sophie Séronie-VivienUNKNOWN SFBC "Biology of renal function and renal failure" working group
Sep 29, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Anne-Sophie BargnouxJean-Paul Cristol
Aug 26, 2010·Current Opinion in Critical Care·Sean M Bagshaw, Rinaldo Bellomo
Jan 20, 2007·Clinical Biochemistry·Stefan Herget-RosenthalWalter Hofmann
Feb 18, 2015·Néphrologie & thérapeutique·Nicolas MaillardChristophe Mariat
Feb 6, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Tam KhuuPeter J Ambrose
Aug 21, 2008·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·Josef Coresh, Priscilla Auguste
Dec 18, 2019·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Francisco José Borrego UtielJuan Antonio Bravo Soto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved