Prediction of HCV load using genotype, liver biomarkers, and clinical symptoms by a mathematical model in patients with HCV infection

Microbiology and Immunology
Samira BasharkhahSeyed Ali Akbar Shamsian

Abstract

Hepatitis C virus (HCV) infection is a major public health problem with about 1.75 million new HCV cases and 71 million chronic HCV infections worldwide. The study aimed to evaluate clinical, serological, molecular, and liver markers to develop a mathematical predictive model for the quantification of the HCV viral load in chronic HCV infected patients. In this cross-sectional study, blood samples were taken from 249 recently diagnosed HCV-infected subjects and were tested for liver condition, viral genotype, and HCV RNA load. Receiver operating characteristics (ROC) curves and multiple linear regression analysis were used to predict the HCV-RNA load. Genotype 3 followed by genotype 1 were the most prevalent genotypes in Mashhad, Northeastern Iran. The maximum levels of viral load were detected in the mixed genotype group, and the lowest levels in the undetectable genotype group. The log of the HCV viral load was significantly associated with thrombocytopenia and higher serum levels of alanine transaminase (ALT). In addition, the log HCV RNA was significantly higher in patients with arthralgia, fatigue, fever, vomiting, or dizziness. Moreover, genotype 3 was significantly associated with icterus. A ROC curve analysis revealed t...Continue Reading

References

Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Alejandro SchijmanJuan Cristina
Apr 15, 2006·International Journal of Medical Sciences·Stéphane Chevaliez, Jean-Michel Pawlotsky
Apr 29, 2006·BMJ : British Medical Journal·Keyur PatelJohn G McHutchison
Jul 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ayman A Abdo
Mar 25, 2010·Virology Journal·Sayyed H Zarkesh-EsfahaniMasoud Edalati
Jul 6, 2012·Journal of Viral Hepatitis·J GuerraA Fontanet
Apr 4, 2013·Hepatitis Monthly·Fatemeh Jahanbakhsh SefidiFarah Bokharaei-Salim
Jul 3, 2013·Nature Reviews. Gastroenterology & Hepatology·Behzad HajarizadehGregory J Dore
Oct 22, 2013·Memórias do Instituto Oswaldo Cruz·Yasser E NassefManal A Hamed
Mar 25, 2014·World Journal of Gastroenterology : WJG·Leonardo de Lucca SchiavonRoberto José de Carvalho-Filho
Mar 29, 2014·Asian Journal of Transfusion Science·Ekta GuptaAashish Choudhary
Apr 3, 2014·Hepatitis Monthly·Hossein HadinedoushanMohsen Akhondi-Meybodi
Jan 23, 2015·Journal of Laboratory Automation·Ronita MukherjeeAngelika Niemz
Feb 13, 2015·World Journal of Virology·Rushna FirdausProvash Chandra Sadhukhan
Jul 4, 2015·World Journal of Hepatology·Lourianne Nascimento Cavalcante, André Castro Lyra
Aug 17, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Saba RiazNaeem Rahid
Apr 14, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
May 2, 2018·The International Journal of Biological Markers·Andrea GallottaGiorgio Fassina

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