Prediction of high-grade meningioma by preoperative MRI assessment.

Journal of Neuro-oncology
Yosuke KawaharaJun-Ichiro Hamada

Abstract

High-grade (World Health Organization grades II and III) meningiomas grow aggressively and recur frequently, resulting in a poor prognosis. Assessment of tumor malignancy before treatment initiation is important. We attempted to determine predictive factors for high-grade meningioma on magnetic resonance (MR) imaging before surgery. We reviewed 65 meningiomas (39 cases, benign; 26 cases, high-grade) and assessed four factors: (1) tumor-brain interface (TBI) on T1-weighted imaging (T1WI), (2) capsular enhancement (CapE), i.e., the layer of the tumor-brain interface on gadolinium-enhanced T1WI (T1Gd), (3) heterogeneity on T1Gd, and (4) tumoral margin on T1Gd. All four factors were useful in distinguishing high-grade from benign meningiomas, according to univariate analysis. On multivariate regression analysis, unclear TBI and heterogeneous enhancement were independent predictive factors for high-grade meningioma. In meningiomas with an unclear TBI and heterogeneous enhancement, the probability of high-grade meningioma was 98%. Our data suggest that this combination of factors obtained from conventional sequences on MR imaging may be useful to predict high-grade meningioma.

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Citations

May 31, 2019·Acta neurochirurgica·Eileen Maria Susanne StreckertBenjamin Brokinkel
Aug 26, 2014·Journal of Neurosurgery·Bon-Jour LinDueng-Yuan Hueng
Apr 3, 2016·Neurosurgical Review·Hao LiJizong Zhao
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Aug 29, 2018·Life Sciences·Tao ZhangLong-Jiang Fang
Dec 10, 2021·Journal of Korean Neurosurgical Society·Sae Min KwonSoo Jeong Nam

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