Prediction of high proliferative index in pituitary macroadenomas using MRI-based radiomics and machine learning

Neuroradiology
Lorenzo UggaArturo Brunetti

Abstract

Pituitary adenomas are among the most frequent intracranial tumors. They may exhibit clinically aggressive behavior, with recurrent disease and resistance to multimodal therapy. The ki-67 labeling index represents a proliferative marker which correlates with pituitary adenoma aggressiveness. Aim of our study was to assess the accuracy of machine learning analysis of texture-derived parameters from pituitary adenomas preoperative MRI for the prediction of ki-67 proliferation index class. A total of 89 patients who underwent an endoscopic endonasal procedure for pituitary adenoma removal with available ki-67 labeling index were included. From T2w MR images, 1128 quantitative imaging features were extracted. To select the most informative features, different supervised feature selection methods were employed. Subsequently, a k-nearest neighbors (k-NN) classifier was employed to predict macroadenoma high or low proliferation index. Algorithm validation was performed with a train-test approach. Of the 12 subsets derived from feature selection, the best performing one was constituted by the 4 highest correlating parameters at Pearson's test. These all showed very good (ICC ≥ 0.85) inter-observer reproducibility. The overall accuracy ...Continue Reading

References

Jun 6, 1992·BMJ : British Medical Journal·P Brennan, A Silman
Dec 2, 2004·Bioinformatics·Jianping HuaEdward R Dougherty
Jun 15, 2005·Journal of Korean Medical Science·Kyung-Il PaekYoun Kim
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Adrian F DalyAlbert Beckers
Apr 4, 2008·Advances and Technical Standards in Neurosurgery·P CappabiancaE De Divitiis
Sep 25, 2014·Handbook of Clinical Neurology·Domenico SolariPaolo Cappabianca
Dec 17, 2014·World Neurosurgery·Paolo CappabiancaMichelangelo de Angelis
Jan 13, 2015·Neuroendocrinology·Eleftherios ChatzellisGregory Kaltsas
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
May 5, 2017·Journal of Magnetic Resonance Imaging : JMRI·Song LiuZhengyang Zhou
Aug 3, 2017·Endocrine Pathology·Ozgur Mete, M Beatriz Lopes
Nov 3, 2017·Cancer Research·Joost J M van GriethuysenHugo J W L Aerts
Nov 15, 2017·Acta neurochirurgica·Joeky T SendersOmar Arnaout
Jan 18, 2018·Journal of Magnetic Resonance Imaging : JMRI·Valeria RomeoArturo Brunetti
Feb 9, 2018·AJNR. American Journal of Neuroradiology·G ZaharchukC P Langlotz
Apr 25, 2018·Brain Tumor Pathology·Naoko Inoshita, Hiroshi Nishioka
Jul 28, 2018·Translational Lung Cancer Research·Timor Kadir, Fergus Gleeson
Nov 21, 2018·Neurosurgical Focus·Todd C HollonStephen E Sullivan
Jun 4, 2019·European Journal of Radiology·Renato CuocoloMassimo Imbriaco

❮ Previous
Next ❯

Citations

Mar 11, 2020·Journal of Magnetic Resonance Imaging : JMRI·Eric K van Staalduinen, Lev Bangiyev
Jul 7, 2020·The British Journal of Radiology·Alberto ConficoniAntonella Bacci
Oct 10, 2020·Journal of Neural Engineering·Lucas Lo VercioNils Daniel Forkert
May 6, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Michele AvanzoGiovanni Mettivier
Mar 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Yae Won ParkSeung-Koo Lee
Jul 3, 2021·Cancers·Agustina La Greca Saint-EstevenStephanie Tanadini-Lang
Jul 29, 2021·Statistical Methods in Medical Research·Hannah JohnsLeonid Churilov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.