Prediction of "hot spots" in interleukin-2 based on informational spectrum characteristics of growth-regulating factors. Comparison with experimental data

Biochimie
I CosićV Vojisavljevic

Abstract

The Resonant Recognition Model (RRM) is a theoretical method for analysis of protein and nucleotide sequences, based on the Fourier transform of the numerical representation of sequences. The amplitude spectrum of this transform is designated Informational Spectrum (IS). There are certain common frequencies in IS of growth-regulating factors. These characteristic frequencies may correlate with their roles in cell proliferation and metabolism, and in antitumor activity. IS of IL-2 has prominent characteristics in the main frequency domain of growth factors, frequency domain of antitumor factors, and frequency domain characteristic for IL-2-alpha receptor. By means of the inverse method for these 3 domains, the amino acids in the sequence of human IL-2 that may be relevant to its biological function, the so-called "hot spots", were predicted. The most probable hot spots, obtained in this way, are in the potential binding site of IL-2 to its receptor, which agrees with experimental data.

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Citations

Jan 12, 1994·Molecular and Cellular Biochemistry·I CosicM T Hearn
Feb 17, 2005·Australasian Physical & Engineering Sciences in Medicine·M SaurenI Cosic
Mar 1, 1995·Bio/technology·I Cosic
Jan 9, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·E PirogovaI Cosic
Mar 7, 2006·Journal of Theoretical Biology·Zachariah Sinkala
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Apr 5, 2002·Protein Engineering·Chafia Hejase de TradIrena Cosic
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Sep 13, 2003·The Journal of Peptide Research : Official Journal of the American Peptide Society·N VeljkovicV Veljkovic
Oct 18, 2020·Interdisciplinary Sciences, Computational Life Sciences·Lingsong YaoYannan Bin

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