Prediction of hypofibrinogenemia and thrombocytopenia at the point of care with the Quantra® QPlus® System.

Thrombosis Research
Bhiken I NaikFrancesco Viola

Abstract

Low fibrinogen and platelet counts are associated with bleeding and the need for transfusion. In this study, we investigated whether the Quantra® QPlus® parameters Fibrinogen Contribution (FCS) and Platelet Contribution (PCS) to clot stiffness could predict commonly used fibrinogen and platelet transfusion thresholds in patients undergoing major surgical procedures. This study used data from a multicenter, prospective observational study of adult patients undergoing cardiac or major orthopedic surgery. Quantra and laboratory assays were performed in parallel at multiple time points. Logistic regression models were used to assess the ability of FCS and PCS to predict fibrinogen and platelet thresholds used to guide transfusions. Receiver operating characteristics (ROC) curves were analyzed to determine the diagnostic accuracy and the optimal FCS and PCS values corresponding to the laboratory-based thresholds. The areas under the ROC curves (AUCs) for FCS at fibrinogen thresholds of <120, 150, and 200 mg/dl ranged from 0.96 to 0.89. Similarly, for PCS at platelet thresholds of <50, 80, 100,000/μl, AUCs ranged from 0.95 to 0.89. The proposed optimal FCS and PCS cutoff values showed high negative predictive value and high sensitivi...Continue Reading

References

Dec 17, 2009·Anesthesia and Analgesia·Jerrold H LevyUNKNOWN Hemostasis Summit Participants
Apr 3, 2012·Anesthesia and Analgesia·Satoru OgawaKenichi A Tanaka
May 16, 2013·The Annals of Thoracic Surgery·Marco RanucciUNKNOWN Surgical and Clinical Outcome Research (SCORE) Group
Aug 9, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Klaus GörlingerKenichi A Tanaka
Mar 19, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Rik H G Olde EngberinkYvonne M C Henskens
Jun 9, 2015·Journal of Neurosurgery. Spine·Bhiken I NaikEdward C Nemergut
May 26, 2016·Anesthesia and Analgesia·Elisa A FerranteFrancesco Viola
Sep 2, 2016·Anesthesia and Analgesia·Bhiken I NaikEdward C Nemergut
May 2, 2017·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerKai Zacharowski
Oct 17, 2017·Journal of Cardiothoracic and Vascular Anesthesia·UNKNOWN Task Force on Patient Blood Management for Adult Cardiac Surgery of the European Association for Cardio-Thoracic Surgery (EADomenico Pagano
Feb 27, 2018·Anesthesia and Analgesia·Patrick SchoberLothar A Schwarte
Oct 4, 2018·Journal of Cardiothoracic and Vascular Anesthesia·Danja S GrovesFrancesco Viola
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint

❮ Previous
Next ❯

Citations

Mar 31, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Prakash A PatelMichael A Mazzeffi
Jul 2, 2021·American Journal of Hematology·David Faraoni, James A DiNardo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Eduardo Cienfuegos-PecinaErik Alejandro Díaz-Chuc
© 2021 Meta ULC. All rights reserved