PMID: 8963028Sep 1, 1995Paper

Prediction of interferon-alpha-induced thyroid dysfunction in patients with chronic hepatitis C

Journal of Gastroenterology and Hepatology
T MurakamiM Onji

Abstract

To predict interferon-alpha (IFN-alpha)-induced thyroid dysfunction, anti-thyroglobulin (anti-TgAb) and anti-thyroid peroxidase antibodies (anti-TPOAb) were determined by radio-immunoassay (RIA) before IFN-alpha treatment in 30 patients with chronic hepatitis C in whom the conventional haemagglutination test had failed to detect anti-thyroid auto-antibodies. Seven patients developed thyroid dysfunction during IFN-alpha treatment (transient thyrotoxicosis in four patients, transient hypothyroidism in two, and Graves' disease in one). Anti-TgAb and/or anti-TPOAb were detectable before IFN-alpha treatment in six of these seven patients, while these antibodies were detected before treatment in only four of 23 patients who did not develop any thyroid dysfunction. The prevalence of these antibodies was significantly higher (P = 0.002) in the former group of patients than in the latter. In four patients with detectable anti-TgAb before treatment but no subsequent thyroid dysfunction, the antibody disappeared during IFN-alpha treatment. Haemagglutination tests for anti-thyroid microsomal antibodies have previously been reported to be a useful predictive marker of IFN-alpha-induced thyroid dysfunction. In conclusion, sensitive detection...Continue Reading

References

Dec 1, 1992·Clinical and Experimental Immunology·H GisslingerM Weissel
Mar 1, 1992·Internal Medicine·Y TaniguchiY Ohta
Aug 1, 1991·Annals of Internal Medicine·L E RönnblomK E Oberg
Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·P BurmanF A Karlsson

❮ Previous
Next ❯

Citations

Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Mikio WatanabeYoshinori Iwatani
Apr 14, 2006·Journal of Viral Hepatitis·A FloreaniUNKNOWN Arsita-one Research Group
Mar 16, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D L Ward, R G Bing-You

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.