Prediction of Large Joint Destruction in Patients With Rheumatoid Arthritis Using 18F-FDG PET/CT and Disease Activity Score

Medicine
Takahito SutoKenji Takagishi

Abstract

The assessments of joint damage in patients with rheumatoid arthritis (RA) are mainly restricted to small joints in the hands and feet. However, the development of arthritis in RA patients often involves the large joints, such as the shoulder, elbow, hip, knee, and ankle. Few studies have been reported regarding the degree of large joint destruction in RA patients. F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) visualizes the disease activity in large joints affected by RA. In this study, the associations between destruction of the large joints and the findings of FDG-PET/CT as well as laboratory parameters were investigated, and factors associated with large joint destruction after the administration of biological therapy were identified in RA patients. A total of 264 large joints in 23 RA patients (6 men and 17 women; mean age of 66.9 ± 7.9 years) were assessed in this study. FDG-PET/CT was performed at baseline and 6 months after the initiation of biological therapy. The extent of FDG uptake in large joints (shoulder, elbow, wrist, hip, knee, and ankle) was analyzed using the maximum standardized uptake value (SUVmax). Radiographs of the 12 large joints per patient obtained a...Continue Reading

References

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Nov 25, 2014·BMC Musculoskeletal Disorders·Koichi OkamuraKenji Takagishi

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Citations

Feb 10, 2017·Rheumatology·Nehal NarayanPeter C Taylor
Dec 23, 2016·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Homaira RahimiChristopher T Ritchlin
May 23, 2018·AJR. American Journal of Roentgenology·Ali GholamrezanezhadHossein Jadvar
Mar 6, 2019·Arthritis & Rheumatology·Ahmed TawakolJon T Giles
Nov 14, 2019·International Journal of Rheumatic Diseases·William Y RaynorJoshua F Baker
Feb 23, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ekaterina ZezinaNadine Biesemann
Apr 8, 2020·Modern Rheumatology·Trang Thuy DamYoshito Tsushima
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Chiara GiraudoSiegfried Trattnig
May 24, 2017·BMC Musculoskeletal Disorders·Lijuan ZhangZhifeng Gu
Jul 28, 2020·Arthritis Research & Therapy·Masahiro TachibanaHirotaka Chikuda
Aug 5, 2021·Arthritis Research & Therapy·D A M Thuy TrangHirotaka Chikuda
Sep 1, 2021·Rheumatology·Manil SubesingheSujith Subesinghe

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Methods Mentioned

BETA
ESR

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SPSS Statistics
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