Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study

JACC. Cardiovascular Imaging
Øyvind H LieKristina H Haugaa

Abstract

This study aimed to identify clinical, electrocardiographic (ECG) and cardiac imaging predictors of first-time life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy (AC). The role of clinical, electrocardiographic, and cardiac imaging parameters in risk stratification of patients without ventricular arrhythmia is unclear. We followed consecutive AC probands and mutation-positive family members with no documented ventricular arrhythmia from time of diagnosis to first event. We assessed clinical, electrocardiographic, and cardiac imaging parameters according to Task Force Criteria of 2010 in addition to left ventricular (LV) and strain parameters. High-intensity exercise was defined as >6 metabolic equivalents. We included 117 patients (29% probands, 50% female, age 40 ± 17 years). During 4.2 (interquartile range [IQR]: 2.4 to 7.4) years of follow-up, 18 (15%) patients experienced life-threatening ventricular arrhythmias. The 1-, 2-, and 5-year incidence was 6%, 9%, and 22%, respectively. History of high-intensity exercise, T-wave inversions ≥V3, and greater LV mechanical dispersion were the strongest risk markers (adjusted hazard ratio [HR]: 4.7 [95% confidence interval (CI): 1.2 to 17.5]; p = 0....Continue Reading

Citations

Mar 27, 2020·Journal of Clinical Medicine·Giulia MattesiAlberto Cipriani
Jul 18, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Andre La Gerche, Hein Heidbuchel
Feb 8, 2020·Cardiology in Review·Amer SayedJason T Jacobson
Mar 11, 2020·Nature Reviews. Cardiology·Gemma Parry-Williams, Sanjay Sharma
Mar 18, 2020·European Cardiology·Alexandros Protonotarios, Perry M Elliott
Jan 21, 2020·Echocardiography·Tomas F CianciulliLucia R Kazelián
Jul 1, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hein HeidbuchelDomenico Corrado
Dec 10, 2020·Circulation. Arrhythmia and Electrophysiology·Julia Cadrin-TourignyCynthia A James
Jan 18, 2020·Journal of the American College of Cardiology·Y Chandrashekhar
Oct 31, 2020·JACC. Clinical Electrophysiology·Esther ScheirlynckKristina H Haugaa
Apr 7, 2021·Journal of the American Heart Association·Øyvind H LieKristina H Haugaa
Apr 9, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christine Rootwelt-NorbergKristina H Haugaa
May 30, 2021·The International Journal of Cardiovascular Imaging·Mathilde Musoni FalsingTor Biering-Sørensen
Nov 2, 2020·JACC. Cardiovascular Imaging·Øyvind H LieKristina H Haugaa
Jul 15, 2021·Heart·Domenico Corrado, Cristina Basso
Jul 28, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pasquale VergaraPaolo Della Bella
Nov 5, 2021·Frontiers in Cardiovascular Medicine·Julia Martínez-SoléEsther Zorio
Dec 7, 2021·Frontiers in Cardiovascular Medicine·Diego Segura-RodríguezJuan Jiménez-Jáimez

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