Prediction of lymph node manifestations in malignant lymphoma: significant role of volumetric compared with established metric lymph node analysis in multislice computed tomography

Journal of Computer Assisted Tomography
M PueskenJ Wessling

Abstract

Comparison of 2-dimensional and semiautomated 3-dimensional (3D) measurements to distinguish between benign and malignant lymph nodes in patients with malignant lymphoma. Whole-body positron emission tomography-computed tomography (PET-CT) was performed in 33 patients before therapy for malignant lymphoma. Two hundred fifty-seven peripheral lymph nodes (mean size, 13.4 +/- 5.4 mm) were evaluated independently by 2 radiologists, both manually and with the use of semiautomated segmentation software. Long-axis diameter (LAD), short-axis diameter (SAD), maximal 3D diameter, volume, and elongation were measured. Positron emission tomography-CT and PET-CT follow-up and/or histology served as the reference standard. Statistical analysis encompassed intraclass correlation coefficients and receiver operating characteristic curves. The standard of reference revealed involvement in 116 (45%) of 257 lymph nodes. Manual and semiautomated LAD and SAD showed good correlation with intraclass coefficients of 0.85 and 0.72, respectively. Semiautomated prediction of malignant lymph nodes revealed the highest areas under the receiver operating characteristic curves for volume (0.760; 95% confidence interval [CI], 0.639-0.887) followed by SAD (0.74...Continue Reading

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Nov 5, 2013·IEEE Transactions on Medical Imaging·Frank HeckelHorst K Hahn
Aug 20, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Paul FlechsigFrederik L Giesel
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