Abstract
Lymph node metastasis (LNM) is a strong prognostic factor in many solid cancers, including head and neck squamous cell carcinomas (HNSCC), and LNM can be dependent upon primary tumor biology, as well as tumor dimension. Here, we investigate the relative risk of LNM in accordance to tumor dimension and biology in HNSCC subsites. Medical data of 295 HNSCC patients who had undergone the initial curative surgery (oral tongue 174, oropharynx 75, hypopharynx 46) were analyzed to identify the significant predictive factor for LNM. Tumor volume and thickness were set as tumor dimensional variables, and biological variables included lymphovascular, perineural invasion, and tumor differentiation. Statistical analyses were conducted to assess the predictability of LNM from variables, and subgroup analyses according to the tumor subsites. In addition, we evaluated the impacts of tumor dimension and biological variables on the treatment outcomes and survival in HNSCC subsites. The overall tumor dimension and biological variables had a similar impact on the prediction of LNM in HNSCC (area under the curve, 0.7682 and 0.7717). The prediction sensitivity of LNM in oral tongue cancer was mainly dependent on tumor dimension, while LNM in oro- an...Continue Reading
References
Mar 1, 1992·Cancer·L CerezoJ Otero
Jul 1, 1990·Cancer·J P ShahA K Poddar
Jul 1, 1986·Cancer·C MooreR A Greenberg
Jan 15, 1993·Cancer·C R LeemansG B Snow
Jun 2, 2004·Nature Reviews. Cancer·Klaus Pantel, Ruud H Brakenhoff
Aug 9, 2005·Head & Neck·Christophe Le TourneauChristian Borel
Sep 15, 2005·Head & Neck·Jacques BernierJ L Lefèbvre
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Jul 16, 2008·Oral Oncology·H B JonesB Musgrove
Aug 9, 2008·Molecular Cancer Therapeutics·Timothy P PaderaRakesh K Jain
Sep 12, 2008·The New England Journal of Medicine·Robert I Haddad, Dong M Shin
Nov 22, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Hirofumi AkitaShingi Imaoka
Oct 17, 2009·Annals of Surgical Oncology·Mete GoerkemSandro J Stoeckli
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 11, 2010·The Lancet Oncology·Shanthi MarurArlene A Forastiere
Jul 16, 2010·Head & Neck·Joost L KnegjensCoen R Rasch
Jul 24, 2010·Annals of Surgical Oncology·Masayuki TomifujiAkihiro Shiotani
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
May 10, 2011·International Journal of Radiation Oncology, Biology, Physics·Anna StronginMohan Suntharalingam
Jul 1, 2011·Cancer·Ian GanlyJatin Shah
Nov 28, 2012·Cancer·Ian GanlyJatin P Shah
Jan 31, 2013·Annals of Surgical Oncology·Tseng-Cheng ChenPei-Jen Lou
Oct 2, 2013·SpringerPlus·Ann SmeetsMarie-Rose Christiaens
Mar 8, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gilbert O FruhwirthGreg E D Mullen
Citations
Jun 22, 2005·BMC Cancer·Lorenzo Lo MuzioFrancesco Carinci
Nov 13, 2012·PloS One·Marion de ToledoGilles Gadea
Mar 31, 2018·Oral and Maxillofacial Surgery·Christoph KlingelhöfferTobias Ettl
Jan 29, 2019·Head & Neck·Lu-Lu YeHong-Mei Ying
Jun 6, 2015·Head & Face Medicine·Susanne JungJohannes Kleinheinz
Jan 27, 2018·Oncotarget·Jeung Hui PyoJae J Kim
Dec 23, 2016·Head & Neck·Ivica Luksic, Petar Suton
May 8, 2018·Head & Neck·Manish MairPankaj Chaturvedi
Aug 31, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xu QianAndreas E Albers
Nov 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bok-Soon LeeChul-Ho Kim
Feb 27, 2021·Cancer Communications·Jia KouYing Sun
Feb 11, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xiaohui YuanLiang Zhou