Prediction of microclimate pH in poly(lactic-co-glycolic acid) films

Journal of the American Chemical Society
Amy G DingSteven P Schwendeman

Abstract

An equilibrium mathematical model that accurately predicts microclimate pH (mupH) in thin biodegradable polymer films of poly(lactic-co-glycolic acid) (PLGA) is described. mupH kinetics was shown to be primarily a function of: (i) kinetics of water-soluble acid content and composition in the polymer matrix and (ii) polymer/water partition coefficient of water-soluble degradation products (P(i)). Polymers were coated on standard pH glass electrodes, and mupH was measured potentiometrically. Water-soluble acid distribution and content in PLGA films were determined by pre-derivatization HPLC. Polymer degradation products partitioned favorably in the polymer phase relative to water (P(i) range: approximately 6-100), and P(i) increased with increasing hydrophobicity of the acidic species according to a linear free energy law related to reversed phase HPLC retention time for the corresponding derivatized bromophenacyl esters. The mupH predicted by the model was in excellent agreement with experimental mupH for several PLGAs as a function of time and PLGA lactic/glycolic acid ratio. These data may be useful to slowly release pH-sensitive PLGA-encapsulated bioactive substances and provide a general framework for predicting partitioning...Continue Reading

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Citations

Jul 4, 2007·Journal of Materials Science. Materials in Medicine·Lisa Maria EhrenfriedRuth E Cameron
Jul 16, 2008·Pharmaceutical Research·Amy G Ding, Steven P Schwendeman
Jun 13, 2009·Journal of Biomaterials Science. Polymer Edition·Jeffrey R KovacsWilson S Meng
Mar 22, 2012·Expert Opinion on Drug Delivery·Doris GabrielDaniel S Kohane
Apr 3, 2015·Pharmaceutical Research·Mehrnoosh ShirangiCornelus F van Nostrum
Sep 1, 2010·Therapeutic Delivery·Andrew L Lewis, Lisbeth Illum
Jul 16, 2008·International Journal of Pharmaceutics·Christian Wischke, Steven P Schwendeman
May 13, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kashappa Goud H DesaiSteven P Schwendeman
Apr 4, 2008·International Journal of Pharmaceutics·Jichao KangSteven P Schwendeman
Oct 30, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ashlee N Ford VersyptRichard D Braatz
Feb 28, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Adam BohrMoritz Beck-Broichsitter
Jun 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Steven P SchwendemanAnna S Schwendeman
Aug 12, 2014·Nature Reviews. Drug Discovery·Samir MitragotriRobert Langer
Feb 8, 2019·Current Pharmaceutical Biotechnology·Tommaso CasaliniGiuseppe Perale
Sep 27, 2012·Angewandte Chemie·Samuel E ReinholdSteven P Schwendeman
Oct 4, 2018·The AAPS Journal·Jia ZhouSteven P Schwendeman
Oct 31, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tinghui LiSteven P Schwendeman
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Vivian Inês Dos SantosMárcio Celso Fredel
Jun 6, 2008·Molecular Pharmaceutics·Kirby C Wong-MoonPaul A Burke
Jul 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Yuji OgawaMitsuru Akashi
Aug 20, 2008·Molecular Pharmaceutics·Wenlei Jiang, Steven P Schwendeman
Sep 27, 2012·Molecular Pharmaceutics·Sam N RothsteinSteven R Little
Jan 11, 2013·Biomacromolecules·Michael T CookVitaliy V Khutoryanskiy
Apr 17, 2015·ACS Applied Materials & Interfaces·Fang YangNing Gu
Sep 5, 2020·Biomacromolecules·Justin K Y Hong, Steven P Schwendeman

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