PMID: 16637275Apr 28, 2006Paper

Prediction of natively unfolded regions in protein chain

Molekuliarnaia biologiia
O V GalzitskaiaM Iu Lobanov

Abstract

We have shown that the ability of a protein to be in globular or in natively unfolded state (under native conditions) may be determined (besides low overall hydrophobicity and a large net charge) by such a property as the average environment density, the average number of residues enclosed at the given distance. A statistical scale of the average number of residues enclosed at the given distance for 20 types of amino acid residues in globular state has been created on the basis of 6626 protein structures. Using this scale for separation of 80 globular and 90 natively unfolded proteins we fail only in 11% of proteins (compared with 17% of errors which are observed if to use hydrophobicity scale). The present scale may be used both for prediction of form (folded or unfolded) of the native state of protein and for prediction of natively unfolded regions in protein chains. The results of comparison of our method of predicting natively unfolded regions with the other known methods show that our method has the highest fraction of correctly predicted natively unfolded regions (that is 87% and 77% if to make averaging over residues and over proteins correspondingly).

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Citations

Nov 8, 2006·Molekuliarnaia biologiia·O V GalzitskaiaM Iu Lobanov
May 23, 2007·Molekuliarnaia biologiia·I N Serdiuk
Oct 1, 2011·Molekuliarnaia biologiia·A L KsenofontovL A Baratova
May 31, 2012·Molekuliarnaia biologiia·M Iu LobanovO V Galzitskaia
Aug 12, 2014·Biochimica Et Biophysica Acta·Pooja RaniParbati Biswas
Oct 2, 2015·International Journal of Molecular Sciences·Jianzong LiJinku Bao

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