Prediction of Nocturnal Hypoglycemia From Continuous Glucose Monitoring Data in People With Type 1 Diabetes: A Proof-of-Concept Study.

Journal of Diabetes Science and Technology
Morten H JensenOle Hejlesen

Abstract

Intensive insulin therapy has documented benefits but may also come at the expense of a higher risk of hypoglycemia. Hypoglycemia is associated with higher all-cause mortality and nocturnal hypoglycemia has been associated with the sudden dead-in-bed syndrome. This proof-of-concept study sought to investigate if nocturnal hypoglycemia can be predicted. Continuous glucose monitoring, meal, insulin, and demographics data from 463 people with type 1 diabetes were obtained from a clinical trial. A total of 4721 nights without or with hypoglycemia (429) were available including data from three consecutive days before the night. Thirty-two features were calculated based on these data. Data were split into 20% participants for evaluation and 80% for training. The optimal feature subset was found from forward selection of the 80% participants with linear discriminant analysis as basis for the classifier. The forward selection resulted in a feature subset of four features. The evaluation resulted in an area under the receiver operating characteristics curve (ROC-AUC) of 0.79 leading to a sensitivity and a specificity of, e.g., 75% and 70%. It was possible to predict nocturnal hypoglycemic episodes with a ROC-AUC of 0.79. A warning at be...Continue Reading

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Citations

Jun 2, 2020·Journal of Diabetes Science and Technology·Darpit DaveMadhav Erraguntla
Apr 17, 2020·Diabetes Technology & Therapeutics·Clara Mosquera-LopezPeter G Jacobs
Apr 22, 2020·Pediatric Diabetes·Chris WorthIndraneel Banerjee
Dec 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Piotr WitkowskiUNKNOWN “Islets for US” Collaborative
Mar 26, 2021·Diabetes/metabolism Research and Reviews·Omar DiouriUNKNOWN HYPO-RESOLVE Consortium

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NCT02825251

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