Prediction of non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastases: evaluation of the tenon score.

Breast Cancer : Basic and Clinical Research
Y AnderssonL Bergkvist

Abstract

Current guidelines recommend completion axillary lymph node dissection (cALND) in case of a sentinel lymph node (SLN) metastasis larger than 0.2 mm. However, in 50%-65% of these patients, the non-SLNs contain no further metastases and cALND provides no benefit. Several nomograms and scoring systems have been suggested to predict the risk of metastases in non-SLNs. We have evaluated the Tenon score. In a retrospective review of the Swedish Sentinel Node Multicentre Cohort Study, risk factors for additional metastases were analysed in 869 SLN-positive patients who underwent cALND, using uni- and multivariate logistic regression models. A receiver operating characteristic (ROC) curve was drawn on the basis of the sensitivity and specificity of the Tenon score, and the area under the curve (AUC) was calculated. Non-SLN metastases were identified in 270/869 (31.1%) patients. Tumour size and grade, SLN status and ratio between number of positive SLNs and total number of SLNs were significantly associated with non-SLN status in multivariate analyses. The area under the curve for the Tenon score was 0.65 (95% CI 0.61-0.69). In 102 patients with a primary tumour <2 cm, Elston grade 1-2 and SLN metastases ≤2 mm, the risk of non SLN metas...Continue Reading

References

May 18, 2001·Archives of Surgery·S L WongUNKNOWN University of Louisville Breast Cancer Sentinel Lymph Node Study Group
Nov 27, 2001·American Journal of Surgery·S F AbdessalamW E Burak
Mar 13, 2002·Annals of Surgical Oncology·Stefano ZurridaUmberto Veronesi
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Oct 3, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H MignotteA Bremond
Jan 7, 2003·Archives of Surgery·J Michael GuentherTheodore X O'Connell
Apr 14, 2005·Annals of Surgical Oncology·Marjolein L SmidtLuc J A Strobbe
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Breast Cancer Study GroupAlan S Coates
Jan 28, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Y de KanterA M M Eggermont
Jan 2, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G P KuijtR M H Roumen
May 9, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony LucciUNKNOWN American College of Surgeons Oncology Group
May 22, 2007·American Journal of Surgery·Riccardo PonzonePiero Sismondi
Jan 29, 2008·Journal of the American College of Surgeons·Charles E CoxDavid Boulware
Feb 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emiel J T Rutgers
Apr 15, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I M C van der PloegB B R Kroon
Jun 14, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P PolettiC Tondini
Dec 3, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I LangerM Zuber
Apr 8, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles CoutantRoman Rouzier
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karl Y BilimoriaDavid J Winchester
Jun 19, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A S GurUNKNOWN Turkish Federation of Breast Disease Associations Protocol MF08-01 investigators
Jun 24, 2010·Breast Cancer Research and Treatment·Liheng ZhouJinsong Lu
Oct 26, 2010·Breast Cancer Research and Treatment·Manon J PepelsVivianne C G Tjan-Heijnen
Feb 10, 2011·JAMA : the Journal of the American Medical Association·Armando E GiulianoMonica Morrow
Jun 15, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marion OrsoniJean-Sébastien Krauth

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Citations

Feb 26, 2013·The British Journal of Surgery·Y AnderssonL Bergkvist
Feb 19, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T F TvedskovN Kroman

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

SPSS

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