Prediction of Nonarrhythmic Mortality in Primary Prevention Implantable Cardioverter-Defibrillator Patients With Ischemic and Nonischemic Cardiomyopathy

JACC. Clinical Electrophysiology
Rui ProvidênciaDAI-PP Investigators

Abstract

The objective of this study was to investigate the feasibility of identifying heart failure patients who are less likely to benefit from implantable cardioverter-defibrillator (ICD) therapy among those eligible for primary prevention ICDs. The cost-effectiveness of ICDs in primary prevention may be improved dramatically. Using a cause-of-death analysis approach, we evaluated the discriminative and predictive values of a risk score with regard to overall mortality and specific causes of death by examining 2,485 patients enrolled in the French Primary Prevention ICD program (2002 to 2012). The risk score included points for New York Heart Association functional class III or greater, age >70 years, QRS duration >120 ms, atrial fibrillation, and glomerular filtration rate <60 ml/min. Sensitivity analyses were performed for ischemic and nonischemic cardiomyopathy, as well as for patients undergoing cardiac resynchronization therapy. After a mean follow-up of 3.0 ± 2.1 years, the overall mortality rate was 5.9 per 100 patient-years (95% confidence interval: 5.4 to 6.5), which increased with the number of risk factors (0 to 5, respectively), as follows: 2.5, 2.9, 4.8, 9.0, 12.3, and 14.8 per 100 patient-years (p < 0.001). The higher m...Continue Reading

References

Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
Apr 20, 2004·Journal of the American College of Cardiology·Henry GreenbergUNKNOWN MADIT-II Investigators
May 21, 2004·The New England Journal of Medicine·Michael R BristowUNKNOWN Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Oct 7, 2005·The New England Journal of Medicine·Gillian D SandersDouglas K Owens
Dec 1, 2007·Epidemiology·Jan P Vandenbroucke
Jan 22, 2008·Journal of the American College of Cardiology·Ilan GoldenbergUNKNOWN MADIT-II Investigators
Sep 5, 2008·The New England Journal of Medicine·Jeanne E PooleGust H Bardy
Sep 23, 2008·Journal of the American College of Cardiology·Roderick TungMark E Josephson
Oct 3, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gabor Z DurayStefan H Hohnloser
Oct 8, 2009·Circulation. Cardiovascular Imaging·Christine M Albert
Sep 15, 2010·Circulation·Ilan GoldenbergUNKNOWN Executive Committee of the Multicenter Automatic Defibrillator Implantation Trial II
Jun 2, 2012·Journal of the American College of Cardiology·Alon BarsheshetIlan Goldenberg
Jul 28, 2012·Journal of the American College of Cardiology·Igor KlemRaymond J Kim
Feb 14, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mark S KremersJohn Rumsfeld
Mar 2, 2013·Journal of the American College of Cardiology·Laurence M EpsteinMelanie Maytin
Jan 22, 2014·Journal of the American College of Cardiology·Jeffrey J GoldbergerAlan H Kadish
Mar 13, 2014·Journal of the American College of Cardiology·Michael DommaschGeorg Schmidt

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Citations

Feb 7, 2019·The New England Journal of Medicine·Byron K LeeJeffrey E Olgin
Jan 29, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Aafke C van der HeijdenC Jan Willem Borleffs
Jul 2, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sérgio BarraSharad Agarwal
Feb 8, 2019·The New England Journal of Medicine·Laurent FauchierArnaud Bisson
Apr 16, 2020·International Journal of Cardiology·Pierre PoupinRodrigue Garcia
Nov 5, 2021·Journal of Medical Systems·Nino FijačkoGregor Štiglic

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