Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure

The American Journal of Cardiology
Michael EgstrupIda Gustafsson

Abstract

Our aim was to assess the prognostic impact of a high-sensitivity cardiac troponin T (hs-cTnT) assay in an outpatient population with chronic systolic left ventricular heart failure (HF). Four hundred sixteen patients with chronic HF and left ventricular ejection fraction ≤ 45% were enrolled in a prospective cohort study. In addition to hs-cTnT, plasma amino-terminal pro-B-type natriuretic peptide was measured at baseline. Mean age was 71 years, 29% were women, 62% had coronary artery disease (CAD), mean left ventricular ejection fraction was 31%, and 57% had abnormal level of hs-cTnT. During 4.4 years of follow-up, 211 (51%) patients died. In multivariate Cox regression models, hs-cTnT was categorized as quartiles or dichotomized by the 99th percentile of a healthy population. Adjusted hazard ratios for all-cause mortality for quartiles 2 to 4, with quartile 1 as reference, were 1.4 (95% confidence interval 0.9 to 2.4, p = 0.16) for quartile 2, 1.7 (0.9 to 2.5, p = 0.12) for quartile 3, and 2.6 (1.6 to 4.4, p <0.001) for quartile 4 and 1.7 (1.2 to 2.5, p = 0.003) for abnormal versus normal level of hs-cTnT. In patients without CAD, quartile 4 of hs-cTnT was associated with an adjusted hazard ratio of 6.8. In conclusion, hs-cTn...Continue Reading

References

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Citations

Nov 22, 2013·QJM : Monthly Journal of the Association of Physicians·C J PetrieJ A Abed
Jan 27, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas W BarrettShalini Prasad
Mar 18, 2015·Journal of Cardiovascular Translational Research·Shweta R MotiwalaJames L Januzzi
Dec 3, 2014·The American Journal of Medicine·Justin L GrodinW H Wilson Tang
Sep 29, 2018·Annals of Medicine·Bashir AlaourThomas E Kaier
Apr 11, 2013·Expert Review of Cardiovascular Therapy·Joseph L Blackshear, Thomas G Brott
Jun 21, 2017·Clinical Chemistry·Kai M Eggers, Bertil Lindahl
Nov 21, 2013·Clinical Chemistry·Shweta R MotiwalaMichelle L O'Donoghue
Nov 13, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Serdar TurkmenMustafa Yavuz Selçuk
Jul 29, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Nadia AspromonteMarco Migliardi
Jul 2, 2019·Journal of Cardiovascular Medicine·Erica RoccoLuigi M Biasucci
Dec 18, 2015·Cardiology in the Young·Kimberly Y Lin
Dec 21, 2017·Expert Review of Cardiovascular Therapy·Mark MariathasNick Curzen
Jan 24, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi NakamuraYasuchika Takeishi
Mar 13, 2021·Journal of the American College of Cardiology·Inbar RaberJames L Januzzi

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