Prediction of Pancreatic Cancer Based on Imaging Features in Patients With Duct Abnormalities.

Pancreas
Wansu ChenBechien U Wu

Abstract

Abnormalities of the main pancreatic duct may be an early indicator of pancreatic ductal adenocarcinoma (PDAC). We develop and validate algorithms that predict the risk of PDAC using features identified on cross-sectional imaging and other clinical characteristics collected through electronic medical records. Adult patients with abdominal computed tomography or magnetic resonance imaging in January 2006 to June 2016 demonstrating dilatation of main pancreatic duct were identified. Pancreas-related morphologic features were extracted from radiology reports using natural language processing. The cumulative incidence of PDAC with death as a competing risk was estimated using multistate models. Model discrimination was assessed using c-index. The models were internally validated using bootstrapping. The cohort consisted of 7819 patients (mean age, 71 years; 65% female). A total of 781 patients (10%) developed PDAC within 3 years after the first eligible imaging study. The final models achieved reasonable discrimination (c-index, 0.825-0.833). The 3-year average risk of PDAC in the top 5% of the total eligible patients was 56.0%, more than 20 times of the average risk among the bottom 50% of patients. Prediction models combining ima...Continue Reading

References

Apr 1, 1960·Annals of Surgery·A PAULINO-NETTOI D BARONOFSKY
Jan 24, 2007·AJR. American Journal of Roentgenology·Tomoaki IchikawaHideki Fujii
Mar 17, 2010·Computer Methods and Programs in Biomedicine·Liesbeth C de WreedeHein Putter
Sep 30, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elizabeth C VernaHarold Frucht
Dec 7, 2010·Gastroenterology·Hans F A VasenWouter H de Vos tot Nederveen Cappel
Nov 1, 2011·Bioinformatics·Daniel J Stekhoven, Peter Bühlmann
Dec 1, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wigdan Al-SukhniSteven Gallinger
Oct 2, 2013·The American Journal of Gastroenterology·Bechien U WuEunis W Ngor
Dec 23, 2014·Radiology·Matthias BarralPhilippe Soyer
Oct 23, 2015·Clinical and Translational Gastroenterology·Satish MunigalaBanke Agarwal
May 19, 2018·Gastroenterology·Ayush SharmaSuresh T Chari

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Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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