Prediction of pelvic inflammatory disease among young, single, sexually active women

Sexually Transmitted Diseases
Roberta B NessGynecologic Infection Follow-Through, GIFT, Investigators

Abstract

To assess prediction strategies for pelvic inflammatory disease (PID). One thousand one hundred seventy women were enrolled based on a high chlamydial risk score. Incident PID over a median of 3 years was diagnosed by either histologic endometritis or Centers for Disease Control and Prevention criteria. A multivariable prediction model for PID was assessed. Women enrolled using the risk score were young, single, sexually active, and often had prior sexually transmitted infections. Incident PID was common (8.6%). From 24 potential predictors, significant factors included age at first sex, gonococcal/chlamydial cervicitis, history of PID, family income, smoking, medroxyprogesterone acetate use, and sex with menses. The model correctly predicted 74% of incident PID; in validation models, correct prediction was only 69%. Our data validate a modified chlamydial risk factor scoring system for prediction of PID. Additional multivariable modeling contributed little to prediction. Women identified by a threshold value on the chlamydial risk score should undergo intensive education and screening.

References

Oct 1, 1992·American Journal of Public Health·D ScholesA S Stergachis
Nov 13, 1991·JAMA : the Journal of the American Medical Association·A E WashingtonK K Holmes
Mar 1, 1990·American Journal of Obstetrics and Gynecology·P A MarchbanksH B Peterson
Jul 9, 1982·JAMA : the Journal of the American Medical Association·J KelaghanP M Layde
Aug 1, 1993·American Journal of Epidemiology·A StergachisW E Stamm
May 1, 1993·American Journal of Obstetrics and Gynecology·S D HillisL Westrom
May 23, 1996·The New England Journal of Medicine·D ScholesW E Stamm
Jun 1, 1996·The Journal of Infectious Diseases·J KimaniR C Brunham
May 1, 1996·Sexually Transmitted Diseases·M O JossensR L Sweet
Oct 1, 1996·Obstetrics and Gynecology·J R SchwebkeR L Sweet
Mar 1, 1997·American Journal of Obstetrics and Gynecology·R B NessA Kanbour-Shakir
May 23, 2000·Sexually Transmitted Diseases·A L SussK Bromberg
Feb 28, 2001·Sexually Transmitted Infections·C MarksA Mindel
Apr 17, 2001·American Journal of Obstetrics and Gynecology·J F PeipertUNKNOWN Pelvic Inflammatory Disease Evaluation and Clinical Health Study Investigators
Aug 3, 2001·American Journal of Obstetrics and Gynecology·R B NessUNKNOWN PID Evaluation and Clinical Health (PEACH) Study Investigators
Aug 24, 2001·American Journal of Obstetrics and Gynecology·J M BaetenJ K Kreiss
Sep 10, 2002·Sexually Transmitted Diseases·Sevgi O Aral, Thomas A Peterman
Oct 18, 2002·Obstetrics and Gynecology·Roberta B NessPeter Rice
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Catherine L HaggertyGuiliana Trucco
Mar 20, 2003·Journal of the National Cancer Institute·Peter B BachColin B Begg
May 24, 2003·Epidemiologic Reviews·Jenny L Martino, Sten H Vermund
Dec 10, 2003·Sexually Transmitted Infections·I SimmsL Weström
Jun 29, 2004·The American Journal of Cardiology·Donald M Lloyd-JonesDaniel Levy
Jul 31, 2004·American Journal of Public Health·Roberta B NessUNKNOWN Pelvic Inflammatory Disease Evaluation and Clinical Health Study Investigators
Oct 2, 2004·Obstetrics and Gynecology·Roberta B NessHolly E Richter
Apr 27, 2005·Lancet·David A Grimes, Kenneth F Schulz

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Citations

Oct 27, 2011·Infectious Diseases in Obstetrics and Gynecology·Brandie D TaylorCatherine L Haggerty
Jun 23, 2011·Infection and Drug Resistance·Brandie D Taylor, Catherine L Haggerty
Nov 5, 2008·Journal of American College Health : J of ACH·Jessica Roberts WilliamsHayley Mark
Nov 22, 2013·Archives of Gynecology and Obstetrics·Anjeza XholliAngelo Cagnacci
Sep 11, 2012·Journal of Proteomics·Andy TengLuis M de la Maza
Nov 18, 2011·American Journal of Obstetrics and Gynecology·Todd R JenkinsHeather Greer
Nov 15, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joanne ReekieUNKNOWN Chlamydia and Reproductive Health Outcome Investigators
Apr 25, 2017·The Cochrane Database of Systematic Reviews·Ricardo F SavarisJonathan Ross
Feb 24, 2017·Clinical and Vaccine Immunology : CVI·Luis M de la MazaRobert C Brunham
Aug 26, 2006·Current Opinion in Obstetrics & Gynecology·M Rosanna Gray-Swain, Jeffrey F Peipert
Aug 21, 2020·The Cochrane Database of Systematic Reviews·Ricardo F SavarisJonathan Ross
May 8, 2019·Clinical Practice and Cases in Emergency Medicine·Ryan OffmanAdam Gwizdala
Jan 27, 2019·The Cochrane Database of Systematic Reviews·Carol Páez-CanroHernando G Gaitán
May 20, 2021·American Journal of Clinical Dermatology·Theodora K Karagounis, Miriam K Pomeranz

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