PMID: 11934239Apr 6, 2002Paper

Prediction of poly(ethylene) glycol-drug eutectic compositions using an index based on the van't Hoff equation

Pharmaceutical Research
Devalina LawMichelle A Long

Abstract

To define an index based on the van't Hoff equation that can be used as a screening tool for predicting poly(ethylene) glycol (PEG)-drug eutectic composition. Phase diagrams of PEG with ritonavir, ibuprofen, fenofibrate. naproxen, and griseofulvin were constructed using differential scanning calorimetry, hot stage microscopy and powder X-ray diftractometry. Previously reported phase diagrams were also used to test the predictive capability of the index. This work shows that a modified van't Hoff equation can be used to model the drug liquidus line of these phase diagrams. The slope of the liquidus line depends on the melting point (T(f)d) and heat of fusion (deltaH(f)d) of the drug and describes the initial rate at which the eutectic or monotectic point is approached. Based on this finding, a dimensionless index Ic was defined. The index can be calculated from the melting points of the pure components and heat of fusion of the drug. In addition to the compounds listed above, the index was found to predict the eutectic composition for flurbiprofen, temazepam and indomethacin. These compounds range over 150 degrees C in T(f)d, and from 25-65 kJ/mole in deltaH(f)d. Using Ic the approximate eutectic composition for eight different ...Continue Reading

Citations

Apr 2, 2008·Chemical & Pharmaceutical Bulletin·Madhuri NewaChul Soon Yong
May 3, 2011·Chemical & Pharmaceutical Bulletin·Amit Kumar Aggarwal, Shweta Jain
Nov 22, 2008·Archives of Pharmacal Research·Madhuri NewaChul Soon Yong
Feb 10, 2010·Pharmaceutical Development and Technology·Jared A Baird, Lynne S Taylor
Aug 8, 2008·Drug Development and Industrial Pharmacy·Madhuri NewaChul Soon Yong
May 3, 2008·Biological & Pharmaceutical Bulletin·Madhuri NewaChul-Soon Yong
May 8, 2014·Chemical Communications : Chem Comm·Zhi ZhongYanbin Huang
Apr 25, 2013·Drug Development and Industrial Pharmacy·Panagiotis BarmpalexisEmanouil Georgarakis
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
May 12, 2020·ACS Omega·Kaushalendra ChaturvediKenneth R Morris

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