Prediction of positive placebo response among chronic schizophrenic outpatients

The Journal of Nervous and Mental Disease
T TaiminenR K Salokangas

Abstract

We undertook this study to determine whether predictors of positive placebo response in chronic schizophrenic outpatients could be identified. Twelve placebo responders and 33 placebo nonresponders who participated in a parallel-group, double-blind, 12-week clinical drug trial were compared. No significant differences between the groups were found with regard to 16 anamnestic and symptom variables. To investigate further which variables at baseline predicted positive placebo response, a stepwise linear regression model was created. Of the seven variables entered into the model, only high scores in the positive domain of the Positive and Negative Syndrome Scale (delusions, unusual thought content, grandiosity, and suspiciousness/persecution) at baseline predicted significantly positive placebo response (p = .0047). Because the onset of placebo response was gradual, the authors hypothesize that placebo response in chronic schizophrenia consists mainly of two ingredients: nonspecific psychotherapeutic effect caused by the several assessments carried out during the study, and regression toward the mean.

References

Sep 1, 1988·The American Journal of Psychiatry·W Coryell, R Noyes
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jun 1, 1994·The American Journal of Psychiatry·J M Kane
Jun 1, 1994·The American Journal of Psychiatry·S R Marder, R C Meibach
Oct 8, 1994·Lancet·D M Chaput de Saintonge, A Herxheimer
Oct 29, 1994·Lancet·J R Laporte, A Figueras
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·W A Brown
Sep 24, 1994·BMJ : British Medical Journal·J M Bland, D G Altman
Nov 1, 1994·The Journal of Nervous and Mental Disease·J P LindenmayerS Grochowski
Sep 1, 1994·The Journal of Nervous and Mental Disease·A Bystritsky, S V Waikar
Apr 1, 1993·The American Journal of Psychiatry·F M QuitkinD F Klein
Mar 1, 1964·American Journal of Psychotherapy·A K SHAPIRO
Jan 1, 1960·A.M.A. Archives of General Psychiatry·L D HANKOFFN FREEDMAN

❮ Previous
Next ❯

Citations

May 10, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A K EllisJ H Day
Sep 1, 1996·Acta Psychiatrica Scandinavica·R K SalokangasE Syvälahti
Nov 17, 2009·Journal of Clinical Psychopharmacology·Ira D GlickCarla M Canuso
Nov 5, 1997·The Journal of Nervous and Mental Disease·T TaiminenR K Salokangas
Dec 10, 1999·Journal of Clinical Psychopharmacology·T JungermanE Klein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.