Prediction of potential disease-associated microRNAs using structural perturbation method

Bioinformatics
Xiangxiang ZengQuan Zou

Abstract

The identification of disease-related microRNAs (miRNAs) is an essential but challenging task in bioinformatics research. Similarity-based link prediction methods are often used to predict potential associations between miRNAs and diseases. In these methods, all unobserved associations are ranked by their similarity scores. Higher score indicates higher probability of existence. However, most previous studies mainly focus on designing advanced methods to improve the prediction accuracy while neglect to investigate the link predictability of the networks that present the miRNAs and diseases associations. In this work, we construct a bilayer network by integrating the miRNA-disease network, the miRNA similarity network and the disease similarity network. We use structural consistency as an indicator to estimate the link predictability of the related networks. On the basis of the indicator, a derivative algorithm, called structural perturbation method (SPM), is applied to predict potential associations between miRNAs and diseases. The link predictability of bilayer network is higher than that of miRNA-disease network, indicating that the prediction of potential miRNAs-diseases associations on bilayer network can achieve higher acc...Continue Reading

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Citations

Jun 26, 2018·Bioinformatics·Xing ChenJian-Qiang Li
Aug 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingzhe XuJiayin Wang
Apr 2, 2019·PLoS Computational Biology·Cheng LiangJiawei Luo
Jun 28, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Guo MaoWei Zhang
Jul 28, 2019·International Journal of Molecular Sciences·Ping XuanShuxiang Pan
Oct 1, 2019·Journal of Cellular and Molecular Medicine·Leon WongMei-Yuan Cao
Sep 26, 2019·Current Gene Therapy·He ZhuangShu-Lin Liu
Sep 25, 2019·Current Gene Therapy·Tianyi ZhaoYadong Wang
Jun 18, 2019·Briefings in Functional Genomics·Linlin YuanQuan Zou
Jun 18, 2020·Frontiers in Bioengineering and Biotechnology·Qi ChenRan Su
Aug 25, 2020·Nucleic Acids Research·Lin NingDong Wang
Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haiqiong LuoLingzhi Zhu
Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingpu Zhang, Lei Deng
Apr 12, 2019·Frontiers in Microbiology·Xiaoqing RuChunyu Wang
Dec 6, 2019·International Journal of Molecular Sciences·Jiacheng WangLei Deng
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruolan ChenJuan Liu
Nov 28, 2018·International Journal of Molecular Sciences·Ping XuanYong Liu
Jan 2, 2019·International Journal of Molecular Sciences·Haochen ZhaoLei Wang
Feb 26, 2019·Computational and Mathematical Methods in Medicine·Yang LiuLei Wang
Feb 15, 2019·Frontiers in Genetics·Lei DengJingpu Zhang
Jun 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xin LiangQuan Zou

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