Prediction of potential thermostable proteins in Xylella fastidiosa

Journal of Theoretical Biology
M G Van der LindenSávio T Farias

Abstract

The average protein (E+K)/(Q+H) ratio in organisms has already been demonstrated to have a strong correlation with their optimal growth temperature. Employing the Thermo-Search web tool, we used this ratio as a basis to look for thermostable proteins in a mesophile, Xylella fastidiosa. Nine proteins were chosen to have their three-dimensional structures modeled by homology, using mainly proteins from mesophiles as templates. Resulting models featured a high number of hydrophobic interactions, a property that has been previously associated with thermostability. These results demonstrate the interesting possibility of using the (E+K)/(Q+H) ratio to find individual thermostable proteins in mesophilic organisms.

References

Dec 5, 1993·Journal of Molecular Biology·A Sali, T L Blundell
Jun 20, 1993·Journal of Molecular Biology·R A LaskowskiJ M Thornton
Aug 1, 1995·Protein Science : a Publication of the Protein Society·V Z SpassovR Ladenstein
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Jan 23, 1999·Current Opinion in Structural Biology·R Jaenicke, G Böhm
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·P J HaneyG J Olsen
Dec 21, 2000·Current Opinion in Microbiology·C I Kado
Sep 12, 2001·Trends in Biochemical Sciences·A Karshikoff, R Ladenstein
Jan 17, 2002·Functional & Integrative Genomics·R Das, M Gerstein
Jun 26, 2003·Nucleic Acids Research·Elisabeth GasteigerAmos Bairoch
Jul 29, 2004·Current Medicinal Chemistry·Kuo-Chen Chou
Sep 24, 2004·Biochemical and Biophysical Research Communications·Denise OsiroLuiz Alberto Colnago
Oct 27, 2004·Acta Crystallographica. Section D, Biological Crystallography·Gerald F AudetteBart Hazes
Jun 25, 2005·Biochemical and Biophysical Research Communications·Bárbara J HenriquesCláudio M Gomes
Nov 8, 2005·Progress in Neurobiology·Gert LubecJulius Paul Pradeep John

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Citations

Apr 22, 2008·Annual Review of Phytopathology·Subhadeep ChatterjeeSteven Lindow

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