Prediction of pre-eclampsia by an analysis of placenta-derived cellular mRNA in the blood of pregnant women at 15-20 weeks of gestation

BJOG : an International Journal of Obstetrics and Gynaecology
Akihiko SekizawaTakashi Okai

Abstract

A panel of cellular mRNA markers was used to predict the occurrence of pre-eclampsia in pregnant women at 15-20 weeks of gestation. Prospective cohort study. The Department of Obstetrics and Gynaecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Indonesia. Peripheral blood samples from asymptomatic pregnant women. Among 660 women, 62 developed pre-eclampsia at later gestation (pre-eclampsia group) and each case was matched with five controls. Therefore, the RNA expression levels in the cellular component of maternal blood in 62 women with pre-eclampsia were compared with those in 310 controls. The cellular RNA expression levels of genes related to angiogenesis and oxidative stress were compared between pre-eclampsia and control groups. A receiver operating characteristic (ROC) curve was used to analyse the sensitivity of each available marker. A logistic regression analysis was performed to calculate the odds for each woman to be classified as a case. The univariate ROC analysis identified soluble vascular endothelial growth factor receptor-1 (Flt-1) and endoglin (ENG) as the markers with the highest sensitivity. The best multivariate model was obtained by combining Flt-1, ENG, placental growth factor (PlGF...Continue Reading

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Citations

Dec 17, 2009·BMC Pregnancy and Childbirth·Daniel A EnquobahrieTanya Sorenson
Jan 1, 2014·Journal of Clinical Medicine·Antonio Farina
Jul 9, 2014·Nature Reviews. Nephrology·Tinnakorn ChaiworapongsaRoberto Romero
Sep 17, 2011·Biological Research for Nursing·Mandy J Bell, Yvette P Conley
Jun 14, 2015·American Journal of Obstetrics and Gynecology·C Emily KleinrouwelerEwoud Schuit
Dec 13, 2012·Reproductive Sciences·Satoshi MiyagamiTakashi Okai
Mar 9, 2018·Journal of Cellular and Molecular Medicine·Shannon FallenKai Wang
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Premila PaivaStephen Tong
Dec 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Silvia GalbiatiMaddalena Smid
Jun 16, 2019·International Journal of Molecular Sciences·Barbora KonečnáGabriela Repiská
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Dec 16, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Berthold Huppertz
Oct 27, 2020·Epigenetics Insights·Allison H RietzeMandy J Schmella

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