Prediction of pregnancy after frozen-thawed embryo transfer via in vivo intrauterine oxidation-reduction potential measurements: a pilot study

Reproductive Medicine and Biology
Hitomi NakamuraTadashi Kimura

Abstract

During the implantation period, the uterus goes through many complex, orchestrated changes, including alterations of the glycocalyx that are due to sialylation, sulfation, and fucosylation. A previous mouse study showed that the in vivo intrauterine oxidation-reduction potential (ORP) aided in determining the alterations in the uterine endometrium that are suitable for implantation and for evaluating prospective uterine receptivity, while the in vivo intrauterine pH did not. It was assessed if the in vivo intrauterine ORP could be a useful parameter to predict pregnancy in women. A prospective cohort study was conducted for patients who had received a frozen-thawed single embryo transfer in a programmed, hormonally controlled cycle. The in vivo intrauterine ORP was measured 3 times during the treatment cycle, at cycle days 9-10, 1 day before progesterone administration and immediately before the embryo transfer. The amount of in vivo intrauterine ORP at 9-10 days after the start of menstrual bleeding was significantly lower in the pregnant group than in the non-pregnant group. A receiver-operator characteristic curve analysis of the intrauterine ORP as a predictor of non-conception showed an area under the curve of 0.80. The in...Continue Reading

References

Aug 1, 1992·Journal of Reproduction and Fertility·Z ZhuB A Fenderson
Jun 11, 1999·The New England Journal of Medicine·A J WilcoxC R Weinberg
Jan 18, 2003·Science·Asgerally T Fazleabas, J Julie Kim
Jan 18, 2003·Science·Olga D GenbacevSusan J Fisher
Dec 17, 2005·Epidemiology·Chanley M SmallMichele Marcus
Jan 19, 2010·Paediatric and Perinatal Epidemiology·Rafael T MikolajczykRajeshwari Sundaram
Mar 16, 2017·Fertility and Sterility·Darcy E Broughton, Kelle H Moley

❮ Previous
Next ❯

Citations

May 14, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
pregnancy test
pregnancy tests

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Reproduction, Fertility, and Development
Hitomi NakamuraTadashi Kimura
The Journal of Obstetrics and Gynaecology of the British Empire
R STEIN-WERBLOWSKY
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ye HeZhaolian Wei
© 2022 Meta ULC. All rights reserved