Prediction of prognosis and renal outcome in lupus nephritis.

Lupus Science & Medicine
Ioannis ParodisFrédéric A Houssiau

Abstract

Lupus nephritis (LN) is a severe manifestation of SLE, characterised by subendothelial and/or subepithelial immune complex depositions in the afflicted kidney, resulting in extensive injury and nephron loss during the acute phase and eventually chronic irreversible damage and renal function impairment if not treated effectively. The therapeutic management of LN has improved during the last decades, but the imperative need for consensual outcome measures remains. In order to design trials with success potentiality, it is important to define clinically important short-term and long-term targets of therapeutic and non-therapeutic intervention. While it is known that early response to treatment is coupled with favourable renal outcomes, early predictors of renal function impairment are lacking. The information gleaned from kidney biopsies may provide important insights in this direction. Alas, baseline clinical and histopathological information has not been shown to be informative. By contrast, accumulating evidence of pronounced discrepancies between clinical and histopathological outcomes after the initial phase of immunosuppression has prompted investigations of the potential usefulness of per-protocol repeat kidney biopsies as ...Continue Reading

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Citations

Jul 2, 2020·Lupus·Maria Francisca Moraes-FontesFernanda Carvalho
Sep 1, 2020·AACN Advanced Critical Care·Erin K Gasser, Hildy M Schell-Chaple
Jun 13, 2020·Journal of Nephrology·Claudio PonticelliGabriella Moroni
Apr 24, 2021·Global Pediatric Health·Maria Kristianti SariEggi Arguni
Jul 11, 2021·Paediatric Drugs·Vitor Cavalcanti TrindadeClovis Artur Silva
Jun 25, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Gabriella MoroniClaudio Ponticelli

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Methods Mentioned

BETA
biopsies
biopsy
bio
psy
electron microscopy
dissection

Software Mentioned

REBIOLUP

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