Prediction of progression-free survival and response to paclitaxel plus carboplatin in patients with recurrent or advanced cervical cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Takeshi HisamatsuTadashi Kimura

Abstract

The aim of this study was to identify predictors of the response to paclitaxel-carboplatin chemotherapy (TC) in recurrent or patients with advanced cervical cancer. The records of 61 consecutive women with recurrent or advanced cervical cancer who were treated with TC were retrospectively reviewed. Data regarding their primary disease, follow-up, recurrence, and the activity and toxicity of TC were collected. Multivariate analysis was performed using the Cox proportional hazards regression model to identify predictors of the response to TC. Survival was calculated using the Kaplan-Meier method and compared using the log-rank test. Overall, TC was well tolerated and displayed a response rate of 60.7% (19 complete response and 18 partial response). The median progression-free survival was 14 months for all patients and 20 months for the responders. Grade 3 to grade 4 toxicities were observed in 51 patients (83.6%). Multivariate analysis revealed that performance status, symptom status, and prior chemotherapy were independent prognostic predictors of a poor response. Patient survival was inversely correlated with the number of these prognostic factors. When the patients were divided into 2 prognostic groups (low risk: patients wit...Continue Reading

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Citations

Aug 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guoliu YeYusheng Liu
Jun 14, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuxin LiuYunqing Cai
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Jul 10, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Seiji MabuchiTadashi Kimura
Sep 20, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Seiji MabuchiTadashi Kimura
Mar 6, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Seiji MabuchiTadashi Kimura
Nov 12, 2020·Anais Da Academia Brasileira De Ciências·Jisette G NÚÑezAlessandra N Bruno

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