Prediction of Progression-Free Survival in Patients With Advanced, Well-Differentiated, Neuroendocrine Tumors Being Treated With a Somatostatin Analog: The GETNE-TRASGU Study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Alberto Carmona-BayonasRocio Garcia-Carbonero

Abstract

Somatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well-differentiated, gastroenteropancreatic (GEP) neuroendocrine tumors; however, benefit from treatment is heterogeneous. The aim of the current study was to develop and validate a progression-free survival (PFS) prediction model in SSA-treated patients. We extracted data from the Spanish Group of Neuroendocrine and Endocrine Tumors Registry (R-GETNE). Patient eligibility criteria included GEP primary, Ki-67 of 20% or less, and first-line SSA monotherapy for advanced disease. An accelerated failure time model was developed to predict PFS, which was represented as a nomogram and an online calculator. The nomogram was externally validated in an independent series of consecutive eligible patients (The Christie NHS Foundation Trust, Manchester, United Kingdom). We recruited 535 patients (R-GETNE, n = 438; Manchester, n = 97). Median PFS and overall survival in the derivation cohort were 28.7 (95% CI, 23.8 to 31.1) and 85.9 months (95% CI, 71.5 to 96.7 months), respectively. Nine covariates significantly associated with PFS were primary tumor location, Ki-67 percentage, neutrophil-to-lymphocyte ratio, alkaline phosphatase, extent of liver...Continue Reading

References

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Jul 12, 2014·The New England Journal of Medicine·Martyn E CaplinUNKNOWN CLARINET Investigators
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Aug 14, 2018·Endocrinology and Metabolism Clinics of North America·Mark StevensonRajesh V Thakker

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Mariana Gomes-PorrasCristina Álvarez-Escolá
Oct 17, 2020·CNS Neuroscience & Therapeutics·Guanzhang LiWei Zhang
Feb 9, 2021·World Journal of Clinical Cases·Min ChenHai-Tao Wu
Apr 3, 2021·Frontiers in Endocrinology·Bilal Haider ShamsiXue Qun Chen
Apr 15, 2021·Asia-Pacific Journal of Clinical Oncology·Michael MichaelMeredith Cummins
Oct 2, 2021·Scandinavian Journal of Gastroenterology·Tianbao LiaoLu-Huai Feng
Jan 29, 2021·Neuroendocrinology·Paula Jimenez-FonsecaRocio Garcia-Carbonero

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Software Mentioned

visreg
rms
Hmisc
GETNE
CLARINET
RECIST
R
mgcv
TRASGU
pammtools

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