Abstract
Currently available prognostic tools appear unable to adequately predict recurrence and progression in non muscle-invasive bladder carcinomas. We aimed to assess the prognostic value of immunohistochemical evaluation of the cell cycle markers p53, p16 and pRb. Paraffin blocks were obtained from 78 cases of pTa and pT1 transitional cell carcinomas, for which long-term follow-up was available. Representative sections were stained using antibodies against p53, p16 and pRb. Altered marker expression was found in 45, 17 and 30% of cases, respectively. Concurrent alteration of two or three markers occurred in 19% of cases, and was significantly associated with grade and stage. In univariate survival analysis, the concurrent alteration of any two markers was significantly associated with progression. The greatest risk was produced by alteration of both p53 and p16, which increased the risk of progression by 14.45 times (95% confidence interval (CI) 3.10-67.35). After adjusting for grade and stage, this risk was 7.73 (CI 1.13-52.70). The markers did not generally predict tumour recurrence, except in the 25 pT1 tumours. In these, p16 alteration was associated with a univariate risk of 2.83 (CI 1.01-7.91), and concurrent p53 and p16 alte...Continue Reading
References
Feb 1, 1988·Molecular and Cellular Biology·C A FinlayA J Levine
Jan 1, 1973·International Urology and Nephrology·W Vahlensieck, L Weissbach
Jan 1, 1994·British Journal of Cancer·C J FisherR R Millis
Jan 1, 1995·British Journal of Cancer·J SerthU Jonas
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·C Cordon-CardoA Pellicer
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L LacombeV E Reuter
Jul 2, 1998·British Journal of Cancer·R Abdel-FattahJ Lunec
Dec 10, 1998·The American Journal of Pathology·V G GorgoulisC Kittas
Feb 18, 1999·Oncogene·W F BenedictB Czerniak
Jun 22, 1999·British Journal of Cancer·G A NiehansJ Geradts
Jul 8, 1999·The American Journal of Pathology·I OrlowC Cordon-Cardo
Feb 27, 2001·European Urology·P KorkolopoulouP Davaris
Jul 31, 2001·Molecular Pathology : MP·M A Knowles
Dec 26, 2001·European Urology·M G FriedrichH Huland
Oct 10, 2002·Urologia Internationalis·Ching-Chiang YangWen-Chi Chen
Feb 1, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L L SantosC S Lopes
Feb 8, 2003·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel Rohan, Stanislav Komenda
Apr 15, 2003·The Journal of Pathology·John R W MastersUNKNOWN MRC Superficial Bladder Cancer Group Mitomycin-C Trial Collaborators
Citations
Jan 11, 2013·ISRN Urology·Hans OlssonStaffan Jahnson
Aug 29, 2006·Journal of Clinical Pathology·C MianA Pycha
Jan 30, 2013·BMC Urology·Hans OlssonStaffan Jahnson
Mar 13, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Andrea BrunnerAlexandar Tzankov
Jul 11, 2006·Urologia Internationalis·Enver VardarAli Riza Ayder
Aug 22, 2007·World Journal of Urology·Anirban P MitraRichard J Cote
Oct 23, 2009·American Journal of Clinical Pathology·Kumiko NakazawaRyohei Katoh
Dec 19, 2015·Disease Markers·Yasuyoshi Miyata, Hideki Sakai
Mar 29, 2006·BJU International·Harry W Herr, S Machele Donat
May 21, 2016·Disease Markers·Xiaoning GanGang Chen
Sep 9, 2005·Cancer·Shuya HiraoKarl T Kelsey
Feb 19, 2010·International Journal of Surgical Pathology·Natalia BuzaVinita Parkash
Apr 12, 2018·Medicine·Xiaohong PuQing Huang
Oct 28, 2005·Proteomics·Jonathan P TolsonClaudia A Mueller
Apr 1, 2005·International Journal of Cancer. Journal International Du Cancer·Iman J SchultzJacques B de Kok
Oct 5, 2010·Journal of Korean Medical Science·Kyungji LeeAhwon Lee
Dec 13, 2006·The Journal of Urology·Harry W HerrGuido Dalbagni
Oct 26, 2006·World Journal of Urology·Christopher Y Thomas, Dan Theodorescu
Sep 17, 2014·The Kaohsiung Journal of Medical Sciences·Ching-Hsiu YangSheau-Fang Yang
Oct 2, 2009·BJU International·Richard T BryanKar Keung Cheng
Jun 29, 2010·Histopathology·Ian ProctorGareth H Williams
Jul 27, 2005·Journal of Lower Genital Tract Disease·Peter A DrewDaylene L Ripley
Jan 23, 2008·American Journal of Clinical Pathology·Samia GonzalezXavier Leroy
Feb 9, 2007·Nature Clinical Practice. Urology·Richard E Hautmann
Feb 23, 2011·Der Urologe. Ausg. A·M Burger, F Vom Dorp
Nov 24, 2012·Revista do Colégio Brasileiro de Cirurgiões·Daniel Cury OgataLetícia Elizabeth Augustin Czeczko
Feb 22, 2007·Cancer·Kesavan EsuvaranathanMing Teh
Apr 29, 2019·Journal of Cancer Research and Clinical Oncology·Ana María ChirifeGabriel Casas
Dec 16, 2019·Gene·Maryam Moradi BinabajSeyed Mahdi Hassanian