Prediction of radiotherapy response with a 5-microRNA signature-based nomogram in head and neck squamous cell carcinoma

Cancer Medicine
Lin ChenWeiping Wen

Abstract

Radiotherapy is unlikely to benefit all patients with head and neck squamous cell carcinoma (HNSCC). Therefore, novel method is warranted to predict the radiotherapy response. Our study aimed to construct a microRNA (miRNA)-based nomogram to predict clinical outcomes of patients with HNSCC receiving radiotherapy. We screened out 56 differential miRNAs by analyzing 44 paired tumor and adjacent normal samples miRNA expression profiles from The Cancer Genome Atlas (TCGA). A total of 307 patients with HNSCC receiving adjuvant radiotherapy were randomly divided into a training set (n = 154) and a validation set (n = 153). In the training set, we combined the differential miRNA profiles with clinical outcomes, and LASSO regression model was applied to establish a 5-miRNA signature. The prediction accuracy of the 5-miRNA signature was further validated. In addition, target genes of these miRNAs were predicted, and Gene Ontology (GO) analysis as well as KEGG pathway analysis was executed. A 5-miRNA signature including miR-99a, miR-31, miR-410, miR-424, and miR-495 was identified. With a cutoff value of 1.2201 from Youden's index, the training set was divided into high-risk and low-risk groups, and the 5-year overall survival was signif...Continue Reading

References

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Citations

Nov 30, 2019·Expert Review of Molecular Diagnostics·Tomasz PowrózekTeresa Małecka-Massalska
Feb 11, 2020·Radiation and Environmental Biophysics·Francesca PasiRosanna Nano
Jan 29, 2020·Cancers of the Head & Neck·Mara S SerafiniCarlo Resteghini
May 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cyrus ChargariEric Deutsch
Nov 19, 2020·Heliyon·Soudeh Ghafouri-FardZeinab Shirvani Farsani
Oct 10, 2021·Current Opinion in Virology·Dayna MasonNham Tran
Nov 28, 2021·Molecular Biology Reports·Sethu Thakachy SubhaHasni Idayu Saidi

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Methods Mentioned

BETA
ubiquitination

Software Mentioned

DESeq
GeneCards
R package “ pROC
TargetScan
tile
R
R package “ glmnet
mirwalk
LASSO
R Foundation for Statistical

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