Prediction of red cell and blood volumes distribution by various nomograms: do current nomograms overestimate?

Transfusion
Stein HolmeDeanna McNeil

Abstract

Currently used formulas for estimation of a person's red cell volume (RCV) by weight and height are decades old and were based on the use of 51Cr isotopes and on a sample population, which may not be reflective of today's population. In this study, the accuracy and precision of the use of 99mTc RCV measurements in volunteers more typical of today's population were evaluated. The subjects were volunteers who met the requirements for a standard blood donation. The mean +/- standard deviation (SD) 99mTc RCV for 127 males (mean weight, 83.2 kg; height, 180 cm) was 2062 +/- 339 mL, and for 101 females (mean weight, 69.5 kg; height, 166 cm) it was 1320 +/- 201 mL. These results were highly correlated with RCV results with the standard extrapolation 51Cr method with stored red blood cells (RBCs) and highly consistent (within +/-10%) by repeated measurements with the same 22 donors over a 3.5-year period. The RCV results correlated with estimates from the current formulas, but were on average 11 to 14 percent lower. The studies demonstrated that 99mTc is a reproducible and precise method for determination of a person's RCV and that current formulas may significantly overestimate the RCV of today's population. This is likely the result ...Continue Reading

References

Jul 1, 1992·Transfusion Medicine Reviews·W A Heaton
Sep 1, 1992·British Journal of Haematology·T E KeeganE J Nelson
Aug 15, 1998·Vox Sanguinis·S Holme
Dec 1, 1953·The Journal of Clinical Investigation·H CHAPLINH VETTER
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal

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Citations

Mar 18, 2009·Journal of Clinical Apheresis·Joshua SpaeteJoseph D Sweeney
Aug 13, 2008·Transfusion·Christopher R France, Jay E Menitove
Feb 2, 2010·Transfusion·Jorge A RiosUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II
Oct 4, 2014·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Y Ozier
Nov 20, 2016·Transfusion·Ralph R VassalloHany Kamel
Aug 15, 2021·Transfusion·George B SchreiberToby Simon

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