Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer.

ESMO Open
Christian H BergslandRagnhild A Lothe

Abstract

There is a need for improved selection of patients for adjuvant chemotherapy after resection of non-metastatic colorectal cancer (CRC). Regulator of chromosome condensation 2 (RCC2) is a potential prognostic biomarker. We report on the establishment of a robust protocol for RCC2 expression analysis and prognostic tumour biomarker evaluation in patients who did and did not receive adjuvant chemotherapy. RCC2 was analysed in 2916 primary CRCs from the QUASAR2 randomised trial and two single-hospital Norwegian series. A new protocol using fluorescent antibody staining and digital image analysis was optimised. Biomarker value for 5-year relapse-free survival was analysed in relation to tumour stage, adjuvant chemotherapy and the molecular markers microsatellite instability, KRAS/BRAF V600E/TP53 mutations and CDX2 expression. Low RCC2 expression was scored in 41% of 2696 evaluable samples. Among patients with stage I-III CRC who had not received adjuvant chemotherapy, low RCC2 expression was an independent marker of inferior 5-year relapse-free survival in multivariable Cox models including clinicopathological factors and molecular markers (HR 1.45, 95% CI 1.09 to 1.94, p=0.012, N=521). RCC2 was not prognostic in patients who had re...Continue Reading

References

Apr 7, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharlene GillRichard M Goldberg
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Jun 29, 2007·Journal of the National Cancer Institute·Cornelis J A PuntJean-Yves Douillard
Sep 10, 2009·Science Signaling·Jonathan D HumphriesMartin J Humphries
Sep 27, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollA Cervantes
Feb 28, 2013·Molecular Cancer·Mitsuhiro MatsuoMasatsugu Moriyama
Jul 19, 2014·Methods : a Companion to Methods in Enzymology·Peter W HamiltonManuel Salto-Tellez
Jan 13, 2015·Clinical Colorectal Cancer·Bengt GustavssonFernando Gibson
Feb 24, 2015·Nature Genetics·Alexandre CalonEduard Batlle
Apr 26, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarle BruunRagnhild A Lothe
Jan 21, 2016·The New England Journal of Medicine·Piero DalerbaMichael F Clarke
Apr 30, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DienstmannJ Guinney
Jun 14, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bo PangYan Jin
Nov 5, 2017·Molecular Systems Biology·Martin FrejnoBernhard Kuster
Mar 9, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J SmebyR A Lothe
Feb 16, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shipeng GongGuangping Zhang
Oct 24, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nair LopesJarle Bruun
Apr 16, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F PagèsJ-F Emile

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Methods Mentioned

BETA
surgical resection

Software Mentioned

survMisc
RStudio
Vectra 3 Imaging
survival
R
QUASAR2
survminer

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