PMID: 8598968Mar 1, 1996Paper

Prediction of respiratory distress syndrome by the novel dipalmitoyl phosphatidylcholine test

Obstetrics and Gynecology
J G AlvarezJ Ludmir

Abstract

To determine the accuracy of a new test that measures the concentration in amniotic fluid (AF) of dipalmitoyl phosphatidylcholine (DPPC) in predicting respiratory distress syndrome (RDS). The neonatal respiratory status of 176 newborns delivered within 72 hours of sampling was correlated with the concentration of DPPC, fluorescence polarization (TDx-FLM), lecithin-sphingomyelin ratio (L/S), and phosphatidyl-glycerol (Amniostat-FLM) in AF. Thirty infants developed RDS (17%), all correctly predicted with DPPC values less than 12 micrograms/mL (sensitivity 100%). Only six of the 146 cases with no RDS had DPPC values less than 12 micrograms/mL (specificity 96%). The overall accuracy of the DPPC test was 98% compared with 70% for TDx-FLM, 71% for the L/S, and 67% for Amniostat-FLM. Receiver operating characteristic analysis area was 0.98 +/- 0.01, indicating that the DPPC test is superior to both the TDx-FLM and L/S tests. The DPPC test is an accurate predictor of RDS and fetal lung maturity.

References

Nov 8, 1979·The New England Journal of Medicine·J TordayE E Lawson
Nov 1, 1976·British Journal of Obstetrics and Gynaecology·M ShinitzkyD M Serr
Jul 1, 1990·Medical Decision Making : an International Journal of the Society for Medical Decision Making·M G HuninkC B Begg

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Citations

Mar 22, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D E M Abd El AalMohamed Y El-Kabsh
Nov 14, 1997·Obstetrics and Gynecology·E R MyersJ Ludmir
Jan 28, 1999·American Journal of Respiratory Cell and Molecular Biology·L J MugliaJ A Majzoub
May 29, 2004·American Journal of Obstetrics and Gynecology·Paola G BlancoJuan G Alvarez
Mar 7, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·J G AlvarezJ Ludmir

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