Prediction of respiratory outcome in extremely low gestational age infants.

Neonatology
Richard B ParadAnne Greenough

Abstract

Bronchopulmonary dysplasia (BPD) is a commonly used outcome for randomized neonatal trials. The aim of the present study was to determine whether a diagnosis of BPD or respiratory morbidity (RM1 or RM2) at 12 months corrected age better predicted subsequent RM in extremely low gestational age infants (23-28 weeks of gestation). Initial analysis was undertaken in a development cohort of 76 infants who underwent pulmonary function tests (PFTs) at 12 months corrected age. Parents completed infant respiratory diaries 2 weeks before the PFTs. Analysis was then undertaken in a validation cohort of 227 infants whose parents completed a 4-week respiratory diary when their infant was 12 months corrected age. BPD at 28 days (BPD28d) and 36 weeks post-menstrual age (BPD36w), RM1 (≥3 days and/or nights of cough, wheeze, and/or medicine use) and RM2 (≥4 days and/or nights of cough, wheeze, and/or respiratory medicine use) each week for 2 weeks at 12 months corrected age were assessed with regard to prediction of respiratory outcomes at 24 months documented by respiratory health questionnaires. BPD28d and BPD36w were not significantly associated with any respiratory outcome. Areas under the receiver operating characteristic curves were signi...Continue Reading

Associated Clinical Trials

Jan 9, 2017·Shucheng ZhangShucheng Zhang

Citations

Dec 25, 2015·Expert Review of Respiratory Medicine·Anne Greenough, Ingran Lingam
Apr 28, 2016·The Journal of Pediatrics·Carl T D'AngioUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jan 26, 2017·Yonsei Medical Journal·Yun Sil ChangWon Soon Park
Nov 20, 2016·Acta Paediatrica·Delaney HinesUNKNOWN International Network for Evaluating Outcomes (iNeo) of Neonates
Aug 29, 2019·Pediatric Pulmonology·Valentina Dell'OrtoDaniele De Luca
Oct 19, 2017·Experimental and Therapeutic Medicine·Zhifang DuRuijuan Wang
May 14, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniele De LucaLhousseine Touqui
Dec 2, 2020·Therapeutic Innovation & Regulatory Science·Sarah SheehanSusan McCune
Mar 3, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Kristyn S BeamRichard B Parad
Nov 28, 2017·The Journal of Pediatrics·Robin SteinhornUNKNOWN International Neonatal Consortium

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