Prediction of response to splenectomy in patients with idiopathic thrombocytopenic purpura

World Journal of Surgery
A ShojaiefardS Abdollahzade

Abstract

Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by destruction of opsonized platelets in the reticuloendothelial system, particularly the spleen, and by resulting low platelet counts. Splenectomy is the standard second-line treatment for patients with ITP who do not respond to corticosteroids. In the present study we determined predictive factors for the response of patients with ITP to splenectomy. For thirty-one patients with ITP referred from the Hematology Department of Shariati Hospital, open surgical splenectomy was performed between February 2002 and December 2004. All potentially important variables of response were collected and analyzed to determine predictive parameters. Older patients (>52) responded less positively than younger patients (<52) to splenectomy (p<0.01). Likewise, patients with a sustained remission after splenectomy had a significantly shorter interval of diagnosis of ITP to splenectomy (p<0.05) and shorter duration of corticosteroid therapy before splenectomy (p<0.05). This study confirms that splenectomy is an effective treatment for patients with ITP. Our findings highlight age as the major predictive factor of long-term response to splenectomy in patients with...Continue Reading

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Citations

Dec 13, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Rosario VecchioEmma Cacciola
Jun 7, 2014·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Jorge MontalvoMiguel F Herrera
Oct 19, 2016·European Journal of Haematology·Yue GuanRenchi Yang
May 21, 2016·Journal of Investigative Medicine High Impact Case Reports·Hassan TahirVistasp Daruwalla
Sep 6, 2017·Frontiers in Pediatrics·Rita ConsoliniDavide Spatafora

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