Prediction of Reverse Remodeling at Cardiac MR Imaging Soon after First ST-Segment-Elevation Myocardial Infarction: Results of a Large Prospective Registry

Radiology
Vicente BodiFrancisco J Chorro

Abstract

To assess predictors of reverse remodeling by using cardiac magnetic resonance (MR) imaging soon after ST-segment-elevation myocardial infarction (STEMI). Written informed consent was obtained from all patients, and the study protocol was approved by the institutional committee on human research, ensuring that it conformed to the ethical guidelines of the 1975 Declaration of Helsinki. Five hundred seven patients (mean age, 58 years; age range, 24-89 years) with a first STEMI were prospectively studied. Infarct size and microvascular obstruction (MVO) were quantified at late gadolinium-enhanced imaging. Reverse remodeling was defined as a decrease in left ventricular (LV) end-systolic volume index (LVESVI) of more than 10% from 1 week to 6 months after STEMI. For statistical analysis, a simple (from a clinical perspective) multiple regression model preanalyzing infarct size and MVO were applied via univariate receiver operating characteristic techniques. Patients with reverse remodeling (n = 211, 42%) had a lesser extent (percentage of LV mass) of 1-week infarct size (mean ± standard deviation: 18% ± 13 vs 23% ± 14) and MVO (median, 0% vs 0%; interquartile range, 0%-1% vs 0%-4%) than those without reverse remodeling (n = 296, 58...Continue Reading

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Citations

Jan 9, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Olivier HuttinPierre Y Marie
Apr 11, 2020·Journal of Clinical Medicine·Martin ReindlSebastian Johannes Reinstadler
Apr 9, 2017·The International Journal of Cardiovascular Imaging·Tom HendriksPim van der Harst
Dec 29, 2019·Scientific Reports·Itziar Perez-TerolDaniel Monleon
Mar 14, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Heerajnarain BulluckDerek J Hausenloy
Dec 11, 2020·Circulation. Cardiovascular Imaging·Victor Marcos-GarcesVicente Bodi
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Apr 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Cesar Rios-NavarroVicente Bodi

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Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.