Prediction of seizure outcome improved by fast ripples detected in low-noise intraoperative corticogram

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Tommaso FedeleJohannes Sarnthein

Abstract

Fast ripples (FR, 250-500Hz) in the intraoperative corticogram have recently been proposed as specific predictors of surgical outcome in epilepsy patients. However, online FR detection is restricted by their low signal-to-noise ratio. Here we propose the integration of low-noise EEG with unsupervised FR detection. Pre- and post-resection ECoG (N=9 patients) was simultaneously recorded by a commercial device (CD) and by a custom-made low-noise amplifier (LNA). FR were analyzed by an automated detector previously validated on visual markings in a different dataset. Across all recordings, in the FR band the background noise was lower in LNA than in CD (p<0.001). FR rates were higher in LNA than CD recordings (0.9±1.4 vs 0.4±0.9, p<0.001). Comparison between FR rates in post-resection ECoG and surgery outcome resulted in positive predictive value PPV=100% in CD and LNA, and negative predictive value NPV=38% in CD and NPV=50% for LNA. Prediction accuracy was 44% for CD and 67% for LNA. Prediction of seizure outcome was improved by the optimal integration of low-noise EEG and unsupervised FR detection. Accurate, automated and fast FR rating is essential for consideration of FR in the intraoperative setting.

References

Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Mar 25, 2005·Paediatric Anaesthesia·Isabelle ConstantIsabelle Murat
Jan 31, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Walter J Freeman
Oct 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Eiichirou UrasakiNaoki Akamatsu
Dec 4, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C G BénarF Wendling
Feb 18, 2010·Current Opinion in Neurology·Anatol BraginRichard J Staba
Mar 1, 2012·Annals of Neurology·Maeike ZijlmansJean Gotman
Apr 7, 2012·Progress in Neurobiology·J JacobsJ Gotman
Jun 20, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T FedeleG Curio
Apr 23, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Georgia RamantaniThomas Bast
Mar 4, 2014·Neurosurgery·Georgia RamantaniThomas Bast
Apr 8, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N E C van KlinkM Zijlmans
Aug 31, 2014·Journal of Neuroscience Methods·Gunnar WaterstraatGabriel Curio
Jun 14, 2015·Neurology·Maryse A van 't KloosterMaeike Zijlmans
Jul 19, 2015·International Journal of Surgery·Anita ShettyAarti Kulkarni
Jan 20, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gunnar WaterstraatGabriel Curio
Feb 4, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sergey BurnosJean Gotman
Jul 30, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tommaso FedeleJohannes Sarnthein

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Citations

Feb 26, 2019·Frontiers in Neurology·Aljoscha ThomschewskiBirgit Frauscher
Sep 5, 2019·Journal of Epilepsy Research·Chae Jung Park, Seung Bong Hong
Oct 22, 2020·Epilepsy Currents·Julia Jacobs, Maeike Zijlmans
Mar 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Gunnar WaterstraatGabriel Curio
Mar 23, 2021·Frontiers in Human Neuroscience·Ece BoranJohannes Sarnthein
Apr 20, 2021·Brain Communications·Dorottya CserpanGeorgia Ramantani
May 27, 2021·Nature Communications·Mohammadali SharifshazilehGiacomo Indiveri
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elaine FoleyStefano Seri

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