PMID: 2092945Dec 1, 1990Paper

Prediction of skin permeability of drugs. I. Comparison with artificial membrane

Chemical & Pharmaceutical Bulletin
T HatanakaY Morimoto

Abstract

In order to measure the contribution of lipid and pore (aqueous) pathways to the total skin permeation of drugs, and to establish a predictive method for the steady state permeation rate of drugs, the relationship between permeability through excised hairless rat skin and some physicochemical properties of several drugs were compared with those through polydimethylsiloxane (silicone) and poly(2-hydroxyethyl methacrylate) (pHEMA) membranes, as typical solution-diffusion and porous membranes, respectively. A linear relationship was found between the permeability coefficients of drugs for the silicone membrane and their octanol/water partition coefficients. For the pHEMA membrane, the permeability coefficients were almost constant independent of the partition coefficient. On the other hand, the skin permeation properties could be classified into two types: one involves the case of lipophilic drugs, where the permeability coefficient is correlated to the partition coefficient, similar to the silicone membrane; and the other involves hydrophilic drugs, where the permeability coefficients were almost constant, similar to pHEMA membrane. From the above results, the stratum corneum, the main barrier in skin, could be described as a mem...Continue Reading

Citations

Jan 25, 2013·Therapeutic Delivery·Kenneth B SloanHemamalini Ketha
May 15, 2012·Advanced Drug Delivery Reviews·Longjian ChenGuoping Lian
May 27, 2014·Therapeutic Delivery·John Prybylski, Kenneth B Sloan
Aug 27, 2014·International Journal of Pharmaceutics·Takeshi OshizakaKenji Sugibayashi
Oct 16, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ryotaro MikiYasunori Morimoto
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·Y MorimotoH Omiya
Oct 1, 1993·The Journal of Pharmacy and Pharmacology·K TakahashiN Mizuno
Dec 16, 2000·Pharmaceutical Science & Technology Today·A El-KattanS Haidar
Aug 12, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Bach, B C Lippold
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Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·E ManabeY Morimoto
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Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hiroo MaedaYuji Kurosaki
Feb 2, 2012·Biological & Pharmaceutical Bulletin·Hiroyuki TakeuchiKenji Sugibayashi
Aug 7, 2012·Biological & Pharmaceutical Bulletin·Daisuke HoritaKenji Sugibayashi
Apr 1, 2003·Pharmaceutical Development and Technology·Chuanbin Wu, James W McGinity
Oct 16, 2002·Journal of Pharmaceutical Sciences·Gian Carlo CeschelCelestino Ronchi
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May 12, 2009·International Journal of Pharmaceutics·Scott C WasdoK B Sloan
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Dec 20, 2013·Pharmaceutics·Hiroaki TodoKenji Sugibayashi
Jul 26, 2019·AAPS PharmSciTech·Hiroaki IikuraKenji Sugibayashi

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