Abstract
Heart failure (HF) is associated with an increased risk of sudden cardiac death (SCD). This study sought to demonstrate the incidence of SCD within a multicentre Japanese registry of HF patients hospitalized for acute decompensation, and externally validate the Seattle Proportional Risk Model (SPRM). We consecutively registered 2240 acute HF patients from academic institutions in Tokyo, Japan. The discrimination and calibration of the SPRM were assessed by the c-statistic, Hosmer-Lemeshow statistic, and visual plotting among non-survivors. Patient-level SPRM predictions and implantable cardioverter-defibrillator (ICD) benefit [ICD estimated hazard ratio (HR), derived from the Cox proportional hazards model in the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)] was calculated. During the 2-year follow-up, 356 deaths (15.9%) occurred, which included 76 adjudicated SCDs (3.4%) and 280 non-SCDs (12.5%). The SPRM showed acceptable discrimination [c-index = 0.63; 95% confidence interval (CI) 0.56-0.70], similar to that of original SPRM-derivation cohort. The calibration plot showed reasonable conformance. Among HF patients with reduced ejection fraction (EF; < 40%), SPRM showed improved discrimination compared with the ICD el...Continue Reading
References
Jul 1, 1993·Circulation·K K HoD Levy
Jan 7, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Kaoru TannoUNKNOWN MADIT II. The Multicenter Automtic Defibrillator Implantation Trial
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Mar 15, 2006·Circulation·Wayne C LevyMilton Packer
Mar 21, 2006·Journal of the American College of Cardiology·Eric C SteckerSumeet S Chugh
May 1, 2010·Journal of the American College of Cardiology·Eric D PetersonUNKNOWN NCDR Registry Participants
Dec 21, 2010·American Heart Journal·Paloma GastelurrutiaAntoni Bayes-Genis
Apr 7, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Sanae HamaguchiUNKNOWN JCARE-CARD Investigators
Oct 9, 2012·Journal of Cardiac Failure·Selcuk AdabagRussell V Luepker
Feb 26, 2013·International Journal of Cardiology·Katsuya KajimotoUNKNOWN investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) registry
May 7, 2014·European Journal of Heart Failure·Sang Eun LeeByung-Hee Oh
Dec 6, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroyuki SatakeHiroaki Shimokawa
Jan 3, 2015·Journal of the American College of Cardiology·Karen A HicksShari L Targum
Jul 4, 2015·European Heart Journal. Acute Cardiovascular Care·Kohei WakabayashiUNKNOWN ATTEND investigators
Jul 5, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ramin ShadmanWayne C Levy
May 22, 2016·European Heart Journal·Piotr PonikowskiUNKNOWN ESC Scientific Document Group
Jun 1, 2017·Heart & Lung : the Journal of Critical Care·Brent A WilliamsRobert T Faillace
Jul 6, 2017·The New England Journal of Medicine·Li ShenJohn J V McMurray
Feb 13, 2018·European Journal of Heart Failure·Eiichi AkiyamaUNKNOWN GREAT (Global Research on Acute Conditions Team) Network
May 23, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Yasuyuki ShiraishiJohn G F Cleland
Aug 14, 2018·Journal of Cardiac Failure·Yasuyuki ShiraishiTsutomu Yoshikawa
Aug 25, 2018·JACC. Clinical Electrophysiology·Wayne C LevyGust H Bardy
Mar 20, 2019·Heart and Vessels·Satoshi ShojiShun Kohsaka
Jul 16, 2019·JACC. Heart Failure·Søren Lund KristensenJens Jakob Thune
Citations
Mar 19, 2021·European Heart Journal·Ryoma FukuokaShun Kohsaka
Jun 30, 2021·Heart Failure Reviews·Grigorios GiamouzisFilippos Triposkiadis
Jul 30, 2021·ESC Heart Failure·Ryoma FukuokaTsutomu Yoshikawa
Aug 14, 2021·Journal of Arrhythmia·Hiro YamasakiKazutaka Aonuma
Sep 22, 2021·ESC Heart Failure·Ryuichiro YagiTsutomu Yoshikawa