Prediction of survival from carcinoma of oesophagus and oesophago-gastric junction following surgical resection using an artificial neural network

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
R MofidiS Paterson Brown

Abstract

The aim of this study was to assess the ability of artificial neural network (ANN) in predicting survival in patients undergoing surgical resection for carcinoma of oesophagus and oesophago-gastric junction. From January 1995 to August 2004 patients who underwent surgery for oesophageal and gastric carcinoma were identified. Biographical data, body mass index and pathological minimal cancer dataset were used to design an ANN. Post-operative survival was assessed at 1 and 3 years. Sixty percent of data was used to train and validate the ANN and 40% was used to evaluate the accuracy of trained ANN in predicting survival. This was compared with Union Internacional Contra la Cancrum UICC TNM classification system. Two hundred and sixteen patients underwent resectional surgery for oesophageal and OGJ carcinoma. The accuracy of the ANN in predicting survival at 1 and 3 years was 88% (sensitivity: 92.3%, specificity: 84.5%, DP = 2.3) and 91.5% (sensitivity of 94.61%, specificity: 88%, DP = 2.72), respectively. These figures were significantly better than 1- and 3-year survival predictions using the UICC TNM classification system 71.6% (sensitivity of 66.4%, specificity: 75.5%, and DP < 1) and 74.7% (sensitivity of 70.5%, specificity: ...Continue Reading

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Citations

Jan 1, 2010·Advances and Applications in Bioinformatics and Chemistry : AABC·Najla S Dar-OdehOsama A Abu-Hammad
Jan 7, 2009·The British Journal of Surgery·R MofidiR W Parks
Nov 12, 2013·Technology in Cancer Research & Treatment·M JajroudiM Ahmadzade
May 5, 2017·Cancer Informatics·Hamid Nilsaz-DezfouliMohamad Amin Pourhoseingholi
Aug 19, 2007·The British Journal of Surgery·D A C DeansK C H Fearon
Oct 22, 2009·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Ji Kon Ryu
Oct 1, 2020·World Journal of Gastroenterology : WJG·Yu-Hang ZhangBing Hu

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