Prediction of the fracture load of whole proximal femur specimens by topological analysis of the mineral distribution in DXA-scan images

Bone
Holger BoehmMaximilian Reiser

Abstract

To evaluate scanner-generated images of hip specimens obtained from dual energy X-ray absorptiometry (DXA) by quantitative image analysis of bone mineral distribution in the standard regions of interest (ROI), to predict the ultimate mechanical strength, and to compare the predictive potential with standard densitometry. Femoral bone mineral density (BMD) of 100 hip specimens was obtained by DXA in the total hip, shaft, trochanteric, and neck ROI. Maximum compressive strength (MCS) of the specimens was measured in a mechanical loading device simulating a fall on the greater trochanter. The topology of bone mineral distribution in the scan images was evaluated by image processing methods based on the Minkowski functionals (MF) using the optimized topological parameter MF2D. Correlation and multivariate analysis were employed to assess the statistical potential of BMD and MF2D with respect to predict the mechanical strength of the femur specimens. R2 for the correlation between load-to-failure and BMD varied between 0.73 and 0.79 (exponential curve fit, p<0.001), being highest in the trochanteric ROI. Correlation between load-to-failure of the specimens with the topological parameter MF2D ranged from R2 =0.8 to 0.91 (p<0.001). In...Continue Reading

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Citations

Jun 5, 2010·Medical & Biological Engineering & Computing·Zvi SchechnerRobert S Siffert
May 21, 2013·Medical Engineering & Physics·E Dall'AraD Pahr
Sep 11, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Matthias GebauerJohannes Beckmann
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Dec 14, 2011·Physiological Measurement·P S ToljamoM T Nieminen
Feb 25, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Fatemeh JazinizadehCheryl E Quenneville
Feb 15, 2020·Medical Engineering & Physics·Fatemeh Jazinizadeh, Cheryl E Quenneville
Oct 24, 2020·Journal of Structural Biology·Morgan W BolgerDavid H Kohn

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