Prediction of the physiologic severity of coronary lesions using 3D IVUS: validation by direct coronary pressure measurements

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
T Takayama, J M Hodgson

Abstract

This study was performed to determine whether three-dimensional intravascular ultrasound (3D IVUS) could predict the physiologic significance of coronary lesions. Seventeen lesions were evaluated by means of 3D IVUS, pressure measurements, and quantitative coronary angiography. Physiologic parameters were calculated from the 3D IVUS measures using established equations and compared to values measured by pressure guidewire. IVUS minimum lumen area (MLA) correlated with fractional flow reserve (FFR; R2 = 0.55, P = 0.003) and pressure gradient (R2 = 0.52, P = 0.003). Lesion length (L) had a positive correlation with pressure gradient (R2 = 0.45, P = 0.007). By multivariate analysis, the only significant independent determinant of FFR was MLA/L measured by IVUS. The IVUS-predicted pressure gradient and FFR were well correlated with values measured directly (R2) = 0.88, P < 0.001; R2 = 0.90, P < 0.001, respectively). The physiologic severity of coronary lesions is primarily influenced by lumen area and lesion length and can be established by 3D IVUS.

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Citations

Sep 20, 2002·Journal of Interventional Cardiology·Hanumanth K ReddyPeter A McCullough
Feb 10, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Mohammed SaadGert Richardt
Jun 15, 2010·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Narbeh MelikianBernard de Bruyne
Nov 23, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sebastian ReithMathias Burgmaier
Nov 8, 2012·Clinical Cardiology·Tomokazu IguchiMinoru Yoshiyama
Apr 19, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ramón López-PalopJulian Roldán
Nov 15, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amir LotfiUNKNOWN Society of Cardiovascular Angiography and Interventions
Aug 10, 2005·American Heart Journal·David BroshAmir Lerman
Apr 13, 2011·The American Journal of Cardiology·Chang-Wook NamWilliam F Fearon
Feb 18, 2014·Journal of the American College of Cardiology·Gary S Mintz
Nov 26, 2011·JACC. Cardiovascular Interventions·Michael C McDanielHabib Samady
Jun 30, 2004·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Massoud A LeesarVenu Jasti
Sep 21, 2013·Circulation. Cardiovascular Imaging·Nils P JohnsonK Lance Gould
Oct 3, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Cristiano G BezerraPedro A Lemos
Feb 9, 2019·Circulation. Cardiovascular Interventions·Laurens J C van ZandvoortJoost Daemen
Sep 14, 2017·Expert Review of Cardiovascular Therapy·Michail I PapafaklisLampros K Michalis

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