PMID: 7027720Feb 1, 1981Paper

Prediction of the physiological dead space/tidal volume ratio during anaesthesia/IPPV from simple pre-operative tests

Acta Anaesthesiologica Scandinavica
R Fletcher, B Jonson

Abstract

It can be shown that the assumption of an arbitrary value for VDphys/VT during IPPV can lead to unacceptable degrees of hypo- or hyperventilation. We investigated 33 adult patients scheduled for major non-thoracic surgery, to see if any simple tests could be used to predict VDphys/VT during anaesthesia/IPPV. Fifteen were smokers and 18 non- or ex-smokers. The tests were spirometry, and the single breath tests for CO2 and for N2 (SBT-CO2: SBT-N2). Patients were ventilated during anaesthesia with a Servo Ventilator 900 B, and SBT-CO2 was recorded from a CO2 Analyzer 930. During anaesthesia/IPPV, smokers had significantly greater VDphys/VT (0.40 +/- 0.10 vs. 0.31 +/- 0.07 [P less than 0.01]), and they had more steeply sloping phase IIIs of SBT-CO2 (P less than 0.01) than non- and ex-smokers. For smokers, VDphys/VT was correlated to age (r = 0.75, P less than 0.01), to the slope of phase III of both SBT-CO2 and SBT-N2, and to the ratio of FEV% to its predicted value. For non- and ex-smokers, only one variable, efficiency, describing the shape of SBT-CO2, was correlated to VDphys/VT (r = 0.53, P less than 0.05). Pre-operative prediction of VDphys/VT based on age, smoking history, and SBT-CO2 can reduce the uncertainty in estimating ...Continue Reading

References

Apr 1, 1977·British Journal of Anaesthesia·M K SykesM K Chakrabarti
Dec 1, 1969·Respiration Physiology·N R AnthonisenW R Ross
Sep 1, 1966·The Annals of Thoracic Surgery·A A GarzonK E Karlson

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Citations

Nov 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I A Spahr-SchopferE J Hartley
May 29, 1998·Journal of Clinical Anesthesia·B A GentzC Bay
Dec 31, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Hans ProquittéGerd Schmalisch
Aug 5, 2000·European Journal of Anaesthesiology·R Fletcher, F Boris-Möller
Oct 1, 1986·International Journal of Colorectal Disease·R J AitkenM S Elliot
Jul 27, 2014·The European Respiratory Journal·Johan Petersson, Robb W Glenny

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