Prediction of the very early occurrence of HCC right after DAA therapy for HCV infection

Hepatology International
Yoshihiko OokaMasao Omata

Abstract

Although direct-acting antiviral (DAA) developments make most of hepatitis C virus (HCV) infection curable, some HCV patients develop hepatocellular carcinoma (HCC) after curative treatment of HCV. There is much dispute whether the rapid clearance of the virus enhances the HCC development. In advance of the dispute, we should make clear the characteristics of the patients with very early occurrence and recurrence of HCC after DAA therapy because it was still unclear. We prospectively followed consecutive patients with HCV who had received sofosbuvir (SOF)-based treatment at two hospitals. The baseline characteristics, laboratory data, and liver imaging findings were acquired. We evaluated the rate of HCC occurrence and recurrence within 1-year after DAA therapy and analyzed the associated factors of very early HCC occurrence and recurrence right after SOF therapy. Between July 2013 and October 2016, we studied two cohorts with HCV infection that received SOF therapy. 402 and 462 patients in Yamanashi Central Hospital and Chiba University Hospital were included in this analysis, respectively. The SVR12 rates of genotypes 1 and 2 were 98.9% (561/567) and 96.0% (285/297), respectively. 41 patients developed HCC within 1 year after...Continue Reading

References

Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Apr 8, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Rajender ReddyNezam Afdhal
Dec 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sammy SaabNezam H Afdhal
Jun 12, 2016·Journal of Hepatology·UNKNOWN ANRS collaborative study group on hepatocellular carcinoma (ANRS CO22 HEPATHER, CO12 CirVir and CO23 CUPILT cohorts). Electr
Jan 7, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Giuseppe CabibboUNKNOWN ITA.LI.CA study group
Jun 24, 2017·Gastroenterology·Fasiha KanwalHashem B El-Serag

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Citations

Jun 18, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Victoria T MückeGeorgios Grammatikos
Apr 17, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro Asahina, UNKNOWN Drafting Committee for Hepatitis Management Guidelines, the Japan Society of Hepatology
May 4, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Lung YuWan-Long Chuang
Apr 29, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Roberto CannellaGiuseppe Brancatelli
Sep 4, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shogo TanakaShoji Kubo

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